Portincasa P, Palu' G, Conti G, Pesce A, Chezzi C
Microbiologica. 1984 Apr;7(2):121-32.
Coumermycin A1, a Novobiocin related antibiotic, has been tested in vivo and in vitro for its activity on Influenza A viruses. In a range of concentrations between 3 and 5 micrograms/ml virus production was drastically reduced. The drug was able to inhibit virus release into culture medium also if added up to the sixth hour following infection and its action was reversible within this time. The synthesis of virus induced polypeptides was generally depressed but production of the HA was more deeply inhibited. Viral transcriptase activity in vitro was also affected by the presence of Coumermycin A1 but at doses which seem to high to consider this event as a phenomenon likely to play a role in vivo. It is suggested that the antiviral activity of the drug is mediated by the inhibition of the host cell metabolism.
香豆霉素A1是一种与新生霉素相关的抗生素，已在体内和体外测试其对甲型流感病毒的活性。在3至5微克/毫升的浓度范围内，病毒产生量大幅减少。该药物即使在感染后第六小时添加也能够抑制病毒释放到培养基中，并且其作用在这段时间内是可逆的。病毒诱导的多肽合成通常受到抑制，但血凝素（HA）的产生受到的抑制更深。体外病毒转录酶活性也受到香豆霉素A1的影响，但剂量似乎过高，以至于不能将此现象视为可能在体内起作用的现象。有人认为该药物的抗病毒活性是通过抑制宿主细胞代谢介导的。
