Feisthammel Jürgen, Vu Trung Kien, Hollenbach Marcus, Mössner Joachim, Hoffmeister Albrecht
Division of Gastroenterology, University of Leipzig, Leipzig, Germany -
Division of Gastroenterology, University of Leipzig, Leipzig, Germany.
Minerva Gastroenterol Dietol. 2018 Sep;64(3):193-200. doi: 10.23736/S1121-421X.18.02478-9.
The insufflation of gas during colonoscopy leads to distention of the colon with abdominal discomfort and pain for the patients. Use of CO2 during endoscopy is reported to minimize abdominal discomfort during and after endoscopy. Aim of this study was to find out whether this improvement leads to decreased dosage of sedation drugs in order to improve patient's safety and satisfaction.
In this double-blind, randomized and controlled study 150 Patients referred to colonoscopy were assigned to either CO2 or air insufflation. We recorded basic characteristics of colonoscopy and the amount of drugs used for sedation. Patients and investigators filled out questionnaires to record pain, abdominal bloating and flatulence.
Seventy-two patients were randomized for examination with room air, 78 patients for use of CO2. We found no difference in basic characteristics of colonoscopy (cecal intubation time and procedure time). Both groups were administered the same amount of drugs for sedation. We found only slight improvement of pain, abdominal bloating and flatulence.
The study revealed only moderate positive effects for use of CO2 during colonoscopy. We found only modest improvement of patient's comfort during and after colonoscopy. No reduced doses of drugs for sedation could be recorded.
结肠镜检查期间注入气体可导致结肠扩张，使患者出现腹部不适和疼痛。据报道，在内镜检查期间使用二氧化碳可将内镜检查期间及之后的腹部不适降至最低。本研究的目的是确定这种改善是否会导致镇静药物剂量减少，以提高患者的安全性和满意度。
在这项双盲、随机对照研究中，将150例接受结肠镜检查的患者分为二氧化碳注入组或空气注入组。我们记录了结肠镜检查的基本特征以及用于镇静的药物用量。患者和研究人员填写问卷以记录疼痛、腹部胀气和肠胃胀气情况。
72例患者被随机分配接受空气检查，78例患者使用二氧化碳。我们发现结肠镜检查的基本特征（盲肠插管时间和操作时间）没有差异。两组给予相同剂量的镇静药物。我们发现疼痛、腹部胀气和肠胃胀气仅略有改善。
该研究表明结肠镜检查期间使用二氧化碳仅产生中度积极效果。我们发现结肠镜检查期间及之后患者的舒适度仅略有改善。未记录到镇静药物剂量减少的情况。
