细胞核会产生DNA切口超氧自由基。
Cell nuclei generate DNA-nicking superoxide radicals.
作者信息
Peskin A V, Shlyahova L
出版信息
FEBS Lett. 1986 Jan 6;194(2):317-21. doi: 10.1016/0014-5793(86)80109-0.
PMID:3000831
Abstract
Rat liver nuclei generate superoxide radicals in the presence of NADPH. Active oxygen species induced nicks in nuclear DNA. This was prevented by superoxide dismutase and catalase as well as by anaerobiosis. EDTA-Fe3+ dramatically increased the active oxygen-dependent DNA nicking.
摘要
大鼠肝细胞核在存在烟酰胺腺嘌呤二核苷酸磷酸（NADPH）的情况下会产生超氧自由基。活性氧会诱导核DNA产生切口。超氧化物歧化酶、过氧化氢酶以及厌氧环境可防止这种情况发生。乙二胺四乙酸铁（EDTA-Fe3+）显著增加了活性氧依赖的DNA切口。
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