Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, Guangdong Province, PR China.
Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, Guangdong Province, PR China.
Exp Eye Res. 2018 Nov;176:103-109. doi: 10.1016/j.exer.2018.07.002. Epub 2018 Jul 3.
Previously we developed a mathematical model for describing the retinal nerve fiber bundle (RNFB) trajectories in the human retina. The model was based on Caucasian eyes that were not selected regarding refraction. The aim of this study was to determine the characteristics of the RNFB trajectories in Chinese myopic eyes. We collected high quality red free fundus images from 80 eyes of 80 Chinese myopic subjects (median [interquartile range/range] refraction -3.9 [-6.0 to -2.5/-10 to -1] D). We traced all visible RNFBs (n = 1460) and evaluated their trajectories using the previously published mathematical model. In the superior-temporal region, the RNFB trajectories of the Chinese myopic eyes were similar to that of the Caucasian eyes (86% of trajectories within the 95% central range of the Caucasian model). In the inferior-temporal region, the trajectories of the Chinese low to moderate myopic eyes were also similar to that of the Caucasian eyes (85%); trajectories of the high myopic eyes (spherical equivalent beyond -6.00 D) were clearly less curved (75%). Associations between individual deviations from the model and axial length, retinal vessel course, and optic disc anatomy were studied with multiple linear regression analysis. In the superior-temporal region, the trajectories were associated with retinal vessel course (P = 0.008) and optic disc size (P = 0.016). In the inferior-temporal region, there was a significant association with axial length (P < 0.001), retinal vessel course (P = 0.006), and disc torsion (P = 0.009).
此前，我们开发了一个描述人眼视网膜神经纤维束 (RNFB) 轨迹的数学模型。该模型基于未考虑屈光度的高加索人眼。本研究旨在确定中国人近视眼 RNFB 轨迹的特征。我们从 80 名中国人近视眼（中位数[四分位数间距/范围]屈光度-3.9[-6.0 至-2.5/-10 至-1]D）中收集了高质量的无赤红色眼底图像。我们追踪了所有可见的 RNFB（n=1460），并使用之前发表的数学模型评估它们的轨迹。在上颞区，中国人近视眼的 RNFB 轨迹与高加索人眼相似（95%的轨迹在高加索人模型的中心范围内的 86%）。在下颞区，中国人低中度近视眼的轨迹也与高加索人眼相似（85%）；高度近视眼（等效球镜度超过-6.00D）的轨迹明显弯曲度较低（75%）。我们用多元线性回归分析研究了与模型个体偏差相关的个体轴向长度、视网膜血管走向和视盘解剖结构之间的关系。在上颞区，轨迹与视网膜血管走向（P=0.008）和视盘大小（P=0.016）相关。在下颞区，与轴向长度（P<0.001）、视网膜血管走向（P=0.006）和视盘扭转（P=0.009）有显著关联。
