He F S, Lu B Q, Zhang S L, Dong S W, Yu A, Wang B Y
G Ital Med Lav. 1985 Jan;7(1):5-15.
It was previously reported that chronic exposure to allyl chloride resulted in liver and kidney damage. No neurotoxic effect of allyl chloride had been noticed until two outbreaks of polyneuropathy without liver and kidney dysfunction due to exposure to allyl chloride in China in the early 1970's. Epidemiological and clinical studies done within 1973-1982 revealed that the main risk of industrial exposure to allyl chloride is damage to the peripheral nervous system. Polyneuropathy is thought to be the main clinical manifestation of chronic allyl chloride poisoning. Electroneuromyography is essential and valuable for early diagnosis and biological monitoring. Toxicological and neuropathological studies in rabbits and mice have given the evidence of a pattern of central-peripheral distal axonopathy in peripheral nervous system which has further confirmed the neurotoxicity of allyl chloride found in man. Based on the above results, the maximum allowable concentration of allyl chloride and diagnostic criteria for chronic allyl chloride poisoning are proposed.
此前有报道称，长期接触氯丙烯会导致肝脏和肾脏损伤。直到20世纪70年代初中国发生两起因接触氯丙烯导致的无肝肾功能障碍的多发性神经病疫情，才发现氯丙烯的神经毒性作用。1973年至1982年期间进行的流行病学和临床研究表明，工业接触氯丙烯的主要风险是对外周神经系统的损害。多发性神经病被认为是慢性氯丙烯中毒的主要临床表现。神经肌电图检查对早期诊断和生物监测至关重要且具有重要价值。对兔子和小鼠的毒理学和神经病理学研究提供了外周神经系统中枢-外周远端轴索性神经病模式的证据，进一步证实了在人类中发现的氯丙烯的神经毒性。基于上述结果，提出了氯丙烯的最大允许浓度和慢性氯丙烯中毒的诊断标准。
