Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Max Planck Institute for Medical Research and Institute of Physical Chemistry, Department of Biophysical Chemistry, University of Heidelberg, Germany.
Int J Med Sci. 2018 Jun 13;15(9):944-952. doi: 10.7150/ijms.24111. eCollection 2018.
Bone loss and fractures are consequences of aging, diseases or traumas. Furthermore the increased number of aged people, due to the rise of life expectancy, needs more strategies to limit the bone loss and regenerate the lost tissue, ameliorating the life quality of patients. A great interest for non-pharmacological therapies based on natural compounds is emerging and focusing on the oligostilbene Polydatin, present in many kinds of fruits and vegetables, when resveratrol particularly in red wines. These molecules have been extensively studied due to their antioxidant and anti-inflammatory effects, showing more recently Resveratrol the ability to enhance osteogenic differentiation and bone formation. However, the clinical applications of Resveratrol are limited due to its low bioavailability and rapid metabolism, while its natural glycosilated precursor Polydatin shows better metabolic stability and major abundance in fresh fruits and vegetables. Nevertheless the role of Polydatin on osteogenic differentiation is still unexplored. Mesenchymal stem cells (MSCs) from dental tissues, such as dental bud stem cells (DBSCs), are able to differentiate toward osteogenic lineage: thus we investigated how Resveratrol and Polydatin influence the differentiation of DBSCs, eventually affecting bone formation. Our results showed that Polydatin increases MSCs osteogenic differentiation sharing similar properties with Resveratrol. These results encourage to deepen the effects of this molecule on bone health and its associated mechanisms of action, wishing for the future a successful use in bone loss prevention and therapy.
骨丢失和骨折是衰老、疾病或创伤的后果。此外，由于预期寿命的提高，老年人的数量增加，需要更多的策略来限制骨丢失并再生丢失的组织，从而改善患者的生活质量。人们对基于天然化合物的非药物疗法越来越感兴趣，并将重点放在存在于许多水果和蔬菜中的寡二苯乙烯白藜芦醇上，而不是红葡萄酒中的白藜芦醇。由于这些分子具有抗氧化和抗炎作用，因此已经对它们进行了广泛的研究，最近还显示出白藜芦醇能够增强成骨分化和骨形成的能力。然而，由于其生物利用度低和代谢迅速，白藜芦醇的临床应用受到限制，而其天然糖基化前体白藜芦醇则表现出更好的代谢稳定性和在新鲜水果和蔬菜中的主要丰度。然而，白藜芦醇苷对成骨分化的作用仍有待探索。牙齿组织中的间充质干细胞，如牙芽干细胞（DBSCs），能够向成骨谱系分化：因此，我们研究了白藜芦醇和白藜芦醇苷如何影响 DBSCs 的分化，最终影响骨形成。我们的研究结果表明，白藜芦醇苷可增加间充质干细胞的成骨分化，具有与白藜芦醇相似的特性。这些结果鼓励我们深入研究该分子对骨骼健康的影响及其相关作用机制，希望未来能够成功用于预防和治疗骨丢失。
