Lewis Lauren S, Huffman Kim M, Smith Ira J, Donahue Mark P, Slentz Cris A, Houmard Joseph A, Hubal Monica J, Hoffman Eric P, Hauser Elizabeth R, Siegler Ilene C, Kraus William E
Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, United States.
Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, United States.
Front Physiol. 2018 Jun 29;9:781. doi: 10.3389/fphys.2018.00781. eCollection 2018.
Genetic variation is associated with a number of lifestyle behaviours; it may be associated with adherence and individual responses to exercise training. We tested single nucleotide polymorphisms (SNPs) in the acid ceramidase gene () for association with subject adherence and physiologic benefit with exercise training in two well-characterised randomised, controlled 8-month exercise interventions: STRRIDE I ( = 239) and STRRIDE II ( = 246). Three non-coding SNPs in a linkage disequilibrium block were associated with non-completion: rs2898458(G/T), rs7508(A/G), and rs3810(A/G) were associated with non-completion in both additive (OR = 1.8, 1.8, 2.0; < 0.05 all) and dominant (OR = 2.5, 2.6, 3.5; < 0.05 all) models; with less skeletal muscle expression ( < 0.01) in a subset ( = 60); and poorer training response in cardiorespiratory fitness (peak VO change rs3810 = 0.29, = 0.04; rs2898458 = 0.29, = 0.08; rs7508 = 0.28, = 0.09); and similar in direction and magnitude in both independent exploratory and replication studies. Adherence to exercise may be partly biologically and genetically moderated through metabolic regulatory pathways participating in skeletal muscle adaptation to exercise training.
基因变异与多种生活方式行为有关；它可能与对运动训练的依从性及个体反应相关。我们在酸性神经酰胺酶基因（）中检测了单核苷酸多态性（SNP），以探讨其与在两项精心设计的为期8个月的随机对照运动干预研究（STRRIDE I，n = 239；STRRIDE II，n = 246）中受试者的依从性及运动训练的生理获益之间的关联。一个连锁不平衡区域内的三个非编码SNP与未完成训练有关：rs2898458（G/T）、rs7508（A/G）和rs3810（A/G）在加性模型（OR分别为1.8、1.8、2.0；P均<0.05）和显性模型（OR分别为2.5、2.6、3.5；P均<0.05）中均与未完成训练相关；在一个亚组（n = 60）中，这些SNP与骨骼肌中较低的基因表达相关（P<0.01）；并且在心肺适能的训练反应方面较差（rs3810的峰值VO₂变化β = 0.29，P = 0.04；rs2898458的β = 0.29，P = 0.08；rs7508的β = 0.28，P = 0.09）；在独立的探索性研究和重复性研究中，其方向和幅度相似。运动依从性可能部分地通过参与骨骼肌对运动训练适应的代谢调节途径受到生物学和基因的调控。
