用于周围神经修复的冷冻铸造多孔壳聚糖导管
Freeze-cast Porous Chitosan Conduit for Peripheral Nerve Repair.
作者信息
Yin Kaiyang, Divakar Prajan, Hong Jennifer, Moodie Karen L, Rosen Joseph M, Sundback Cathryn A, Matthew Michael K, Wegst Ulrike G K
机构信息
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, U.S.A.
Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, U.S.A.
出版信息
MRS Adv. 2018;3(30):1677-1683. doi: 10.1557/adv.2018.194. Epub 2018 Feb 20.
Abstract
A novel freeze-cast porous chitosan conduit for peripheral nerve repair with highly-aligned, double layered porosity, which provides the ideal mechanical and chemical properties was designed, manufactured, and assessed in vivo. Efficacies of the conduit and the control inverted nerve autograft were evaluated in bridging 10-mm Lewis rat sciatic nerve gap at 12 weeks post-implantation. Biocompatibility and regenerative efficacy of the porous chitosan conduit were evaluated through the histomorphometric analysis of longitudinal and transverse sections. The porous chitosan conduit was found to have promising regenerative characteristics, promoting the desired neovascularization, and axonal ingrowth and alignment through a combination of structural, mechanical and chemical cues.
摘要
设计、制造并在体内评估了一种新型的冷冻铸造多孔壳聚糖导管，用于周围神经修复，该导管具有高度排列的双层孔隙率，可提供理想的机械和化学性能。在植入后12周时，评估了该导管和对照倒置自体神经移植物在桥接10毫米Lewis大鼠坐骨神经缺损方面的效果。通过对纵向和横向切片的组织形态计量分析，评估了多孔壳聚糖导管的生物相容性和再生效果。结果发现，多孔壳聚糖导管具有良好的再生特性，通过结构、机械和化学线索的组合，促进了所需的新血管形成、轴突向内生长和排列。
相似文献
1
Freeze-cast Porous Chitosan Conduit for Peripheral Nerve Repair.用于周围神经修复的冷冻铸造多孔壳聚糖导管
MRS Adv. 2018;3(30):1677-1683. doi: 10.1557/adv.2018.194. Epub 2018 Feb 20.
2
In vitro and in vivo evaluation of a biodegradable chitosan-PLA composite peripheral nerve guide conduit material.一种可生物降解的壳聚糖-聚乳酸复合周围神经引导导管材料的体外和体内评价
Microsurgery. 2008;28(6):471-9. doi: 10.1002/micr.20514.
3
A compound scaffold with uniform longitudinally oriented guidance cues and a porous sheath promotes peripheral nerve regeneration in vivo.一种具有均匀纵向导向线索和多孔鞘的复合支架促进了体内周围神经的再生。
Acta Biomater. 2018 Mar 1;68:223-236. doi: 10.1016/j.actbio.2017.12.010. Epub 2017 Dec 20.
4
[Study on using a new biodegradable conduit to repairing rat's peripheral nerve defect].[新型可生物降解导管修复大鼠周围神经缺损的研究]
Zhonghua Zheng Xing Wai Ke Za Zhi. 2005 Jul;21(4):295-8.
5
A polymer foam conduit seeded with Schwann cells promotes guided peripheral nerve regeneration.接种雪旺细胞的聚合物泡沫导管促进周围神经的引导性再生。
Tissue Eng. 2000 Apr;6(2):119-27. doi: 10.1089/107632700320748.
6
Design and optimization of a biodegradable porous zein conduit using microtubes as a guide for rat sciatic nerve defect repair.采用微管作为导向，设计和优化一种可生物降解的多孔玉米醇溶蛋白导管，用于修复大鼠坐骨神经缺损。
Biomaterials. 2017 Jul;131:145-159. doi: 10.1016/j.biomaterials.2017.03.038. Epub 2017 Mar 26.
7
Aligned Chitosan-Gelatin Cryogel-Filled Polyurethane Nerve Guidance Channel for Neural Tissue Engineering: Fabrication, Characterization, and In Vitro Evaluation.壳聚糖-明胶共晶水凝胶填充型聚氨酯神经导管用于神经组织工程：制备、表征和体外评价。
Biomacromolecules. 2019 Feb 11;20(2):662-673. doi: 10.1021/acs.biomac.8b01308. Epub 2018 Nov 2.
8
Comparisons of the results of peripheral nerve defect repair with fibrin conduit and autologous nerve graft: An experimental study in rats.纤维蛋白导管与自体神经移植修复周围神经缺损效果的比较：大鼠实验研究
Microsurgery. 2016 Jan;36(1):59-65. doi: 10.1002/micr.22413. Epub 2015 Apr 3.
9
Schwann cells and mesenchymal stem cells in laminin- or fibronectin-aligned matrices and regeneration across a critical size defect of 15 mm in the rat sciatic nerve.层粘连蛋白或纤连蛋白排列基质中的雪旺细胞和间充质干细胞与大鼠坐骨神经15毫米临界尺寸缺损处的再生
J Neurosurg Spine. 2018 Jan;28(1):109-118. doi: 10.3171/2017.5.SPINE161100. Epub 2017 Nov 10.
10
Functional recoveries of sciatic nerve regeneration by combining chitosan-coated conduit and neurosphere cells induced from adipose-derived stem cells.壳聚糖涂层导管联合脂肪来源干细胞诱导的神经球细胞促进坐骨神经再生的功能恢复。
Biomaterials. 2014 Feb;35(7):2234-44. doi: 10.1016/j.biomaterials.2013.11.081. Epub 2013 Dec 20.
引用本文的文献
1
Regenerative Strategies in Treatment of Peripheral Nerve Injuries in Different Animal Models.再生策略在不同动物模型外周神经损伤治疗中的应用。
Tissue Eng Regen Med. 2023 Oct;20(6):839-877. doi: 10.1007/s13770-023-00559-4. Epub 2023 Aug 12.
2
Tensile properties of freeze-cast collagen scaffolds: How processing conditions affect structure and performance in the dry and fully hydrated states.冷冻铸造胶原支架的拉伸性能：加工条件如何影响干燥和完全水合状态下的结构和性能。
J Mech Behav Biomed Mater. 2023 Aug;144:105897. doi: 10.1016/j.jmbbm.2023.105897. Epub 2023 May 11.
3
Bio-Scaffolds as Cell or Exosome Carriers for Nerve Injury Repair.生物支架作为细胞或外泌体载体在神经损伤修复中的应用。
Int J Mol Sci. 2021 Dec 12;22(24):13347. doi: 10.3390/ijms222413347.
4
Modelling-informed cell-seeded nerve repair construct designs for treating peripheral nerve injuries.基于模型的细胞接种神经修复构建设计用于治疗周围神经损伤。
PLoS Comput Biol. 2021 Jul 8;17(7):e1009142. doi: 10.1371/journal.pcbi.1009142. eCollection 2021 Jul.
5
Natural-Based Biomaterials for Peripheral Nerve Injury Repair.用于周围神经损伤修复的天然生物材料
Front Bioeng Biotechnol. 2020 Oct 16;8:554257. doi: 10.3389/fbioe.2020.554257. eCollection 2020.
6
2D and 3D graphical datasets for bamboo-inspired tubular scaffolds with functional gradients: micrographs and tomograms.具有功能梯度的仿竹管状支架的二维和三维图形数据集：显微照片和断层扫描图。
Data Brief. 2020 Jun 17;31:105870. doi: 10.1016/j.dib.2020.105870. eCollection 2020 Aug.
7
Chitosan films for regenerative medicine: fabrication methods and mechanical characterization of nanostructured chitosan films.用于再生医学的壳聚糖薄膜：纳米结构壳聚糖薄膜的制备方法及力学特性
Biophys Rev. 2019 Oct;11(5):807-815. doi: 10.1007/s12551-019-00591-6. Epub 2019 Sep 16.
8
Plant-Derived Nanocellulose as Structural and Mechanical Reinforcement of Freeze-Cast Chitosan Scaffolds for Biomedical Applications.植物源纳米纤维素作为结构和力学增强剂用于冷冻铸造壳聚糖支架在生物医学中的应用。
Biomacromolecules. 2019 Oct 14;20(10):3733-3745. doi: 10.1021/acs.biomac.9b00784. Epub 2019 Sep 26.
9
Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds.冷冻铸造组织支架的体内生物相容性和性能的定量评价。
Biomed Mater. 2020 Jul 23;15(5):055003. doi: 10.1088/1748-605X/ab316a.
10
Values and property charts for anisotropic freeze-cast collagen scaffolds for tissue regeneration.用于组织再生的各向异性冷冻铸造胶原蛋白支架的数值和性能图表。
Data Brief. 2018 Nov 3;22:502-507. doi: 10.1016/j.dib.2018.10.171. eCollection 2019 Feb.
本文引用的文献
1
Bioinspired structural materials.仿生结构材料。
Nat Mater. 2015 Jan;14(1):23-36. doi: 10.1038/nmat4089. Epub 2014 Oct 26.
2
Peripheral nerve morphogenesis induced by scaffold micropatterning.支架微图案化诱导的周围神经形态发生
Biomaterials. 2014 Apr;35(13):4035-4045. doi: 10.1016/j.biomaterials.2014.01.069. Epub 2014 Feb 20.
3
Chitosan tubes of varying degrees of acetylation for bridging peripheral nerve defects.不同乙酰化程度的壳聚糖管用于桥接周围神经缺损。
Biomaterials. 2013 Dec;34(38):9886-904. doi: 10.1016/j.biomaterials.2013.08.074. Epub 2013 Sep 17.
4
Structure-property-processing correlations in freeze-cast composite scaffolds.冷冻铸造复合支架中的结构-性能-处理相关性。
Acta Biomater. 2013 May;9(5):6338-48. doi: 10.1016/j.actbio.2013.01.012. Epub 2013 Jan 12.
5
FDA approved guidance conduits and wraps for peripheral nerve injury: a review of materials and efficacy.美国食品和药物管理局批准的周围神经损伤引导管和包裹物：材料和疗效的综述。
Injury. 2012 May;43(5):553-72. doi: 10.1016/j.injury.2010.12.030. Epub 2011 Jan 26.
6
Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration.组织工程化神经移植物的构建及其在外周神经再生中的应用。
Prog Neurobiol. 2011 Feb;93(2):204-30. doi: 10.1016/j.pneurobio.2010.11.002. Epub 2010 Dec 2.
7
Biomaterials by freeze casting.冷冻铸造法生物材料。
Philos Trans A Math Phys Eng Sci. 2010 Apr 28;368(1917):2099-121. doi: 10.1098/rsta.2010.0014.
Zotero 插件