用于周围神经修复的冷冻铸造多孔壳聚糖导管
Freeze-cast Porous Chitosan Conduit for Peripheral Nerve Repair.
作者信息
Yin Kaiyang, Divakar Prajan, Hong Jennifer, Moodie Karen L, Rosen Joseph M, Sundback Cathryn A, Matthew Michael K, Wegst Ulrike G K
机构信息
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, U.S.A.
Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, U.S.A.
出版信息
MRS Adv. 2018;3(30):1677-1683. doi: 10.1557/adv.2018.194. Epub 2018 Feb 20.
A novel freeze-cast porous chitosan conduit for peripheral nerve repair with highly-aligned, double layered porosity, which provides the ideal mechanical and chemical properties was designed, manufactured, and assessed in vivo. Efficacies of the conduit and the control inverted nerve autograft were evaluated in bridging 10-mm Lewis rat sciatic nerve gap at 12 weeks post-implantation. Biocompatibility and regenerative efficacy of the porous chitosan conduit were evaluated through the histomorphometric analysis of longitudinal and transverse sections. The porous chitosan conduit was found to have promising regenerative characteristics, promoting the desired neovascularization, and axonal ingrowth and alignment through a combination of structural, mechanical and chemical cues.
设计、制造并在体内评估了一种新型的冷冻铸造多孔壳聚糖导管，用于周围神经修复，该导管具有高度排列的双层孔隙率，可提供理想的机械和化学性能。在植入后12周时，评估了该导管和对照倒置自体神经移植物在桥接10毫米Lewis大鼠坐骨神经缺损方面的效果。通过对纵向和横向切片的组织形态计量分析，评估了多孔壳聚糖导管的生物相容性和再生效果。结果发现，多孔壳聚糖导管具有良好的再生特性，通过结构、机械和化学线索的组合，促进了所需的新血管形成、轴突向内生长和排列。
Zotero 插件