Deeb Asma, Attia Salima, Mahmoud Samia, Elhaj Ghada, Elfatih Abubaker
Pediatric Endocrinology Department, Mafraq Hospital, P.O. Box 2951, Abu Dhabi, UAE.
Pediatric Clinic, Police Health Services, Abu Dhabi, UAE.
J Obes. 2018 Jun 12;2018:8626818. doi: 10.1155/2018/8626818. eCollection 2018.
Obesity is a worldwide concern. It is associated with morbidity such as dyslipidemia and liver disease. Childhood obesity has dramatically increased, particularly in the Gulf region. We aim to assess the prevalence of dyslipidemia and fatty liver disease (FLD) in overweight and obese children and analyze the association between different anthropometric measures with dyslipidemia and fatty liver disease.
A descriptive, cross-sectional study conducted on children referred with obesity. BMI percentiles were plotted and standardized waist circumference (WC) was generated. Family history of metabolic syndrome was recorded. Fasting lipid, liver transaminases, and ultrasound scans (US) for those with elevated enzymes were performed. Descriptive statistics were used for quantitative parameters.
216 participants were recruited. Mean ± SD age was 10.58 ± 2.996 years. 55.3% had dyslipidemia; 11.7% had high cholesterol, 28.6% high triglyceride, 32.7% high LDL, and 18.0% low HDL. 51 (84%) had either elevated transaminases. All had liver US, and 43 had FLD. WC was strongly associated with dyslipidemia and FLD (=0.04 and 0.003).
Dyslipidemia is common in overweight, obese children. FLD is prevalent in those with elevated liver transaminases. WC is an easy tool that can be utilized to screen for dyslipidemia and FLD in overweight and obese children.
肥胖是一个全球性问题。它与诸如血脂异常和肝病等发病率相关。儿童肥胖率急剧上升，尤其是在海湾地区。我们旨在评估超重和肥胖儿童血脂异常和脂肪性肝病（FLD）的患病率，并分析不同人体测量指标与血脂异常和脂肪性肝病之间的关联。
对因肥胖前来就诊的儿童进行一项描述性横断面研究。绘制BMI百分位数并计算标准化腰围（WC）。记录代谢综合征家族史。对血脂、肝转氨酶进行空腹检测，并对酶升高者进行超声扫描（US）。对定量参数采用描述性统计。
招募了216名参与者。平均年龄±标准差为10.58±2.996岁。55.3%有血脂异常；11.7%胆固醇高，28.6%甘油三酯高，32.7%低密度脂蛋白高，18.0%高密度脂蛋白低。51例（84%）肝转氨酶升高。所有患者均进行了肝脏超声检查，43例患有脂肪性肝病。腰围与血脂异常和脂肪性肝病密切相关（=0.04和0.003）。
血脂异常在超重、肥胖儿童中很常见。脂肪性肝病在肝转氨酶升高的儿童中普遍存在。腰围是一种可用于筛查超重和肥胖儿童血脂异常和脂肪性肝病的简便工具。
