Fallah Ali, Mohammad-Hasani Azadeh, Colagar Abasalt Hosseinzadeh
-Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran.
J Reprod Infertil. 2018 Apr-Jun;19(2):69-81.
Zinc (Zn) is the second most abundant trace element in human, which can't be stored in the body, thus regular dietary intake is required. This review explained the physiological and pathogenesis roles of zinc in men's health and its potentials in germination, quality of sperm, and fertilization. Our investigation showed that Zn contained many unique properties in human, especially males. The antioxidant quality is one of them. Also, the increased reactive oxygen species levels in the seminal plasma of men who are both infertile and smokers influence the Zn content of seminal plasma in a way that physiology of spermatozoa can be affected as well. Moreover, Zn acts as a toxic repercussionagainst heavy metals and cigarette inflammatory agents. Zinc as a hormone balancer helps hormones such as testosterone, prostate and sexual healthand functions as an antibacterial agent in men's urea system. It plays a role in epithelial integrity, showing that Zn is essential for maintaining the lining of the reproductive organs and may have a regulative role in the progress of capacitation and acrosome reaction. In contrast, Zn deficiency impedes spermatogenesis and is a reason for sperm abnormalities and has a negative effect on serum testosterone concentration. Based on these findings, Zn microelement is very essential for male fertility. It could be considered as a nutrient marker with many potentials in prevention, diagnosis, and treatment of male infertility.
锌（Zn）是人体中含量第二丰富的微量元素，无法在体内储存，因此需要定期从饮食中摄取。这篇综述阐述了锌在男性健康中的生理和发病机制作用，以及其在精子发生、精子质量和受精方面的潜力。我们的研究表明，锌在人体尤其是男性体内具有许多独特特性。抗氧化特性就是其中之一。此外，不育且吸烟的男性精液中活性氧水平升高，会以某种方式影响精液中的锌含量，进而也可能影响精子的生理机能。此外，锌对重金属和香烟中的炎症因子具有毒性拮抗作用。锌作为一种激素平衡剂，有助于调节睾酮等激素，对前列腺和性健康有益，并且在男性泌尿系统中起到抗菌作用。它在上皮完整性方面发挥作用，表明锌对于维持生殖器官的内膜至关重要，并且可能在精子获能和顶体反应过程中起到调节作用。相反，锌缺乏会阻碍精子发生，是精子异常的一个原因，并且会对血清睾酮浓度产生负面影响。基于这些发现，锌微量元素对男性生育能力非常重要。它可被视为一种在男性不育症的预防、诊断和治疗方面具有诸多潜力的营养标志物。
