Halsband Claire, Zapf Antonia, Sixel-Döring Friederike, Trenkwalder Claudia, Mollenhauer Brit
Department of Clinical Neurophysiology University Medical Center Göttingen Germany.
Department of Neurosurgery University Medical Center Göttingen Germany.
Mov Disord Clin Pract. 2018 Mar 1;5(2):171-176. doi: 10.1002/mdc3.12591. eCollection 2018 Mar-Apr.
Rapid eye movement (REM) sleep behavior disorder (RBD) is one of the most specific prodromal indicators for Parkinson's disease (PD).
To test the validity of the RBD-Screening Questionnaire (RBDSQ) in assessing RBD in early PD.
The RBDSQ was completed before video-supported polysomnography (vPSG) by 134 de novo PD patients, 109 matched controls without neurological disorder (CTR) and 30 subjects with idiopathic RBD (iRBD) without clinical signs of PD; results were compared with vPSG-confirmed RBD diagnosis.
Sensitivity/specificity of the RBDSQ for the PD cohort were 0.44/0.84 at the previously published cut-off score of 6 for PD patients, and the area under the curve (AUC) 0.68 (95% CI, 0.56-0.79). By contrast, in the iRBD/CTR cohort the RBDSQ (cut-off = 5) had a sensitivity/specificity of 0.97/0.84 and an AUC of 0.95 (95% CI, 0.90-1.00). Subanalysis of question 6 only (4 subitems asking for dream enactment) at a cut-off score of 1 revealed a sensitivity of 0.74 and a specificity of 0.70 for the de novo PD cohort, AUC was 0.74 (95% CI, 0.63-0.84). RBDSQ is an insufficient screening tool for RBD in de novo PD. New screening tools for RBD assessment need to be developed.
快速眼动（REM）睡眠行为障碍（RBD）是帕金森病（PD）最具特异性的前驱指标之一。
检验RBD筛查问卷（RBDSQ）在评估早期PD患者RBD方面的有效性。
134例新发PD患者、109例无神经系统疾病的匹配对照（CTR）和30例无PD临床体征的特发性RBD（iRBD）患者在视频辅助多导睡眠图（vPSG）检查前完成RBDSQ；将结果与vPSG确诊的RBD诊断结果进行比较。
对于PD队列，在先前公布的PD患者截断分数为6分时，RBDSQ的敏感性/特异性为0.44/0.84，曲线下面积（AUC）为0.68（95%CI，0.56 - 0.79）。相比之下，在iRBD/CTR队列中，RBDSQ（截断分数 = 5）的敏感性/特异性为0.97/0.84，AUC为0.95（95%CI，0.90 - 1.00）。仅对问题6（询问梦境演绎的4个分项）进行亚分析，截断分数为1时，新发PD队列的敏感性为0.74，特异性为0.70，AUC为0.74（95%CI，0.63 - 0.84）。RBDSQ是评估新发PD患者RBD的一种不足的筛查工具。需要开发新的RBD评估筛查工具。
