State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
Nanoscale. 2018 Jul 26;10(29):14190-14200. doi: 10.1039/c8nr01926f.
Transition-metal chalcogenides with an imaging element and tunable optical property are strongly desired as ideal high-efficiency photothermal theranostic agents to diagnose and eliminate tumors. Herein, we report on a one-pot solvothermal strategy to synthesize various porous cobalt sulfide hollow nanospheres (PCSH NSs) and elucidate the relation between PCSH NSs and their optical absorption as a guide to obtain optimal photothermal therapy (PTT) agents. After PEG modification, PEG-PCSH NSs show superexcellent photothermal conversion efficiency (∼70.1%) which is higher than that of binary transition-metal chalcogenides materials reported to date. A low dose (100 μL, 25 ppm) could completely ablate tumors under an 808 nm laser power of 0.7 W cm-2, reducing in vivo long-term residual agent content and thus lowering the possibility of side effects. Additionally, they also exhibit excellent biocompatibility, good photostability and utility for magnetic resonance imaging. Our results indicate that PCSH NSs can be considered as an outstanding PTT agent and give guidance towards the design of other photothermal theranostic agents.
具有成像元件和可调光学性能的过渡金属硫属化物是理想的高效光热治疗剂，可用于诊断和消除肿瘤，因此受到强烈关注。在此，我们报告了一种一锅溶剂热策略，用于合成各种多孔钴硫化物空心纳米球（PCSH NSs），并阐明了 PCSH NSs 与其光学吸收之间的关系，以获得最佳的光热治疗（PTT）剂。经过 PEG 修饰后，PEG-PCSH NSs 表现出超高的光热转换效率（约 70.1%），高于迄今为止报道的二元过渡金属硫属化物材料。在 808nm 激光功率为 0.7W/cm2 的条件下，低剂量（100μL，25ppm）可完全消融肿瘤，减少体内长期残留药物含量，从而降低副作用的可能性。此外，它们还表现出优异的生物相容性、良好的光稳定性和磁共振成像的应用潜力。我们的研究结果表明，PCSH NSs 可作为一种优秀的 PTT 剂，为设计其他光热治疗剂提供了指导。
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