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用于协同治疗和多模态肿瘤成像的近红外光触发复合纳米平台。

A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging.

作者信息

Wu Mingzhou, He Shuqing, Hu Xin, Chen Jingqin, Ha Enna, Ai Fujin, Ji Tao, Hu Junqing, Ruan Shuangchen

机构信息

Shenzhen Key Laboratory of Laser Engineering, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China.

College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, China.

出版信息

Front Chem. 2021 Jul 22;9:695511. doi: 10.3389/fchem.2021.695511. eCollection 2021.

DOI:10.3389/fchem.2021.695511
PMID:34368079
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8339317/
Abstract

Transition-metal chalcogenide compounds with facile preparation and multifunctional elements act as ideal photothermal agents for cancer theranostics. This work synthesizes CuS/5MoS composite nanoflowers and investigates the crystal growth mechanism to optimize the synthesis strategy and obtain excellent photothermal therapy agents. CuS/5MoS exhibits a high photothermal conversion efficiency of 58.7% and acts as a theranostic nanoplatform and demonstrated an effective photothermal-chemodynamic-photodynamic synergetic therapeutic effect in both and tests. Moreover, CuS/5MoS shows strong photoacoustic signal amplitudes and computed tomographic contrast enhancement . These results suggest a potential application of CuS/5MoS composite nanoflowers as photo/HO-responsive therapeutic agents against tumors.

摘要

具有简便制备方法和多功能元素的过渡金属硫属化合物是癌症诊疗的理想光热剂。本工作合成了CuS/5MoS复合纳米花，并研究了晶体生长机制以优化合成策略，从而获得优异的光热治疗剂。CuS/5MoS表现出58.7%的高光热转换效率，可作为一种诊疗纳米平台，并在体内和体外测试中均展现出有效的光热-化学动力学-光动力协同治疗效果。此外，CuS/5MoS显示出较强的光声信号幅度和计算机断层扫描造影增强效果。这些结果表明CuS/5MoS复合纳米花作为光/羟基自由基响应性肿瘤治疗剂具有潜在应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/a732d818ccd4/fchem-09-695511-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/659b877edfbc/fchem-09-695511-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/128c3cde7ca8/fchem-09-695511-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/06851b2e4eb8/fchem-09-695511-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/dea4b780f10f/fchem-09-695511-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/ec925a64ddc8/fchem-09-695511-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/95325c5c12a6/fchem-09-695511-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/f6fbf0f66fb2/fchem-09-695511-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/a732d818ccd4/fchem-09-695511-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/659b877edfbc/fchem-09-695511-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/128c3cde7ca8/fchem-09-695511-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/06851b2e4eb8/fchem-09-695511-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/dea4b780f10f/fchem-09-695511-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/ec925a64ddc8/fchem-09-695511-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/95325c5c12a6/fchem-09-695511-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/f6fbf0f66fb2/fchem-09-695511-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf34/8339317/a732d818ccd4/fchem-09-695511-g008.jpg

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