Huq M Saiful, Hwang Min-Sig, Teo Troy P, Jang Si Young, Heron Dwight E, Lalonde Ronald J
Division of Medical Physics, Department of Radiation Oncology, University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.
Med Phys. 2018 Jul 15. doi: 10.1002/mp.13092.
The International Atomic Energy Agency (IAEA) and the American Association of Physicists in Medicine (AAPM) have jointly published a new code of practice (CoP), TRS483, for the dosimetry of small static photon fields used in external beam radiotherapy. It gave recommendations on how to perform reference dosimetry in nonstandard machine-specific reference (msr) fields and measure field output factors in small fields. The purpose of this work was to perform a dosimetric evaluation of the recommendations given in this CoP.
All measurements were done in a Varian TrueBeam™ STx linear accelerator. Five ionization chambers were used for beam quality measurements, four Farmer type ionization chambers for performing reference dosimetry and two diodes for performing field output factor measurements. Field output factor measurements were done for fourteen field sizes (ranging from 0.5 cm × 0.5 cm to 10 cm × 10 cm). Beam energies used were: 6 MV WFF, 6 MV FFF, 10 MV WFF, and 10 MV FFF. Where appropriate, results from this study were compared with those obtained from the recommendations given in the IAEA TRS398 CoP, AAPM TG51 and TG51 Addendum protocols.
Beam quality measurements show that for all beam energies and for equivalent square msr field sizes ranging from 4 cm × 4 cm to 10 cm × 10 cm, agreement between calculated and measured values of TPR (10) was within 0.6%. When %dd(10,10) was used as beam quality specifier, the agreement was found to be within 0.8%. Absorbed dose to water per unit monitor unit at the depth of maximum dose z in a beam of quality Q, Dw,Qzmax/MU, was determined using both %dd(10,10) and TPR (10) as beam quality specifiers. Measured ratios of D (z )/MU, determined using the two approaches, ranged between 0.999 and 1.000 for all the beam energies investigated. Comparison with TRS398, TG51 and TG51 addendum protocols show that depending on beam energy, the mean values of the ratios TRS398/TRS483, TG51/TRS483, and TG51 Addendum/TRS483 of D (z )/MU determined using both approaches show excellent agreement with TRS398 CoP (to within 0.05%); agreement with TG51 and TG51 addendum was to within 0.3% for all four beam energies investigated. Field output factors, determined using the two methods recommended in the TRS483 CoP, showed excellent agreement between the two methods. For the 1 cm collimator field size, the mean value of the field output factor obtained from an average of the two detectors investigated was found to be 2% lower than the mean value of the uncorrected ratio of readings.
For beams with and without flattening filters, the values of D (z )/MU obtained following the new CoP are found to be consistent with those obtained using TRS398, TG51 and TG51 addendum protocols to within 0.3%. Field output factors for small beams can be improved when the correction factors for different detectors included in TRS483 are appropriately incorporated into their dosimetry.
国际原子能机构(IAEA)和美国医学物理学家协会(AAPM)联合发布了一项关于外照射放疗中小静态光子野剂量测定的新操作规范(CoP),即TRS483。该规范给出了在非标准的特定机器参考(msr)野中进行参考剂量测定以及在小野中测量野输出因子的建议。本研究的目的是对该CoP中的建议进行剂量学评估。
所有测量均在瓦里安TrueBeam™ STx直线加速器上进行。使用五个电离室进行射束质测量,四个 Farmer 型电离室进行参考剂量测定,两个二极管进行野输出因子测量。对14种野尺寸(范围从0.5 cm×0.5 cm到10 cm×10 cm)进行野输出因子测量。使用的射束能量为:6 MV 楔形滤过野(WFF)、6 MV 无楔形滤过野(FFF)、10 MV WFF和10 MV FFF。在适当情况下,将本研究结果与IAEA TRS398 CoP、AAPM TG51和TG51增编协议中的建议结果进行比较。
射束质测量表明,对于所有射束能量以及等效方形msr野尺寸从4 cm×4 cm到10 cm×10 cm,组织空气比(TPR)(10) 的计算值与测量值之间的一致性在0.6%以内。当使用百分深度剂量(%dd(10,10))作为射束质指定参数时,一致性在0.8%以内。在质量为Q的射束中,在最大剂量深度z处每监测单位水的吸收剂量Dw,Qzmax/MU,使用%dd(10,10)和TPR(10)作为射束质指定参数来确定。对于所有研究的射束能量,使用这两种方法确定的D(z)/MU测量比值在0.999至1.000之间。与TRS398、TG51和TG51增编协议的比较表明,根据射束能量,使用这两种方法确定的D(z)/MU的TRS398/TRS483、TG51/TRS483和TG51增编/TRS483比值的平均值与TRS398 CoP具有极好的一致性(在0.05%以内);对于所有四种研究的射束能量,与TG51和TG51增编的一致性在0.3%以内。使用TRS483 CoP中推荐的两种方法确定的野输出因子,两种方法之间具有极好的一致性。对于1 cm准直器野尺寸,从所研究的两个探测器的平均值获得的野输出因子平均值比未校正读数比值的平均值低2%。
对于有和没有均整滤过器的射束,遵循新CoP获得的D(z)/MU值与使用TRS398、TG51和TG51增编协议获得的值在0.3%以内一致。当将TRS483中包含的不同探测器的校正因子适当地纳入其剂量测定中时,小射束的野输出因子可以得到改善。