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非典型糖尿病:诊断挑战。

Atypical diabetes: a diagnostic challenge.

机构信息

Department of Internal Medicine, Region Gävleborg, Gavle, Sweden

出版信息

BMJ Open Diabetes Res Care. 2020 Aug;8(1). doi: 10.1136/bmjdrc-2020-001470.

Abstract

In medical school, we learned how to classify diabetes according to different clinical characteristics. However, at the dawn of the precision medicine era, it is clear that today's clinical reality does not always align well with textbook teachings. The terms juvenile versus elderly-onset diabetes, as well as insulin-dependent versus non-insulin-dependent diabetes, have become obsolete. Contrary to what is often taught severe ketoacidosis may occur in type 2 diabetes. Patients may also suffer from two or more forms of diabetes simultaneously or consecutively. Five authentic cases of diabetes with uncommon characteristics that pose diagnostic challenges are presented here.

摘要

在医学院,我们学习了如何根据不同的临床特征对糖尿病进行分类。然而,在精准医学时代的曙光下,很明显,当今的临床现实并不总是与教科书的教学内容相符。青少年发病型与老年发病型糖尿病、胰岛素依赖型与非胰岛素依赖型糖尿病等术语已经过时。与通常所教授的内容相反,严重酮症酸中毒也可能发生于 2 型糖尿病患者中。患者也可能同时或先后患有两种或多种形式的糖尿病。这里呈现了五个具有罕见特征且对诊断具有挑战性的糖尿病真实病例。

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The integrative biology of type 2 diabetes.2 型糖尿病的综合生物学。
Nature. 2019 Dec;576(7785):51-60. doi: 10.1038/s41586-019-1797-8. Epub 2019 Dec 4.
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The heterogeneous pathogenesis of type 1 diabetes mellitus.1 型糖尿病的异质性发病机制。
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