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Does moisturizing the skin equate with barrier repair therapy?皮肤保湿等同于屏障修复疗法吗？
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Moisturizing treatment of patients with atopic dermatitis and ichthyosis vulgaris improves dry skin, but has a modest effect on gene expression regardless of FLG genotype.对特应性皮炎和寻常型鱼鳞病患者进行保湿治疗可改善皮肤干燥，但无论FLG基因型如何，对基因表达的影响都较小。
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Br J Dermatol. 1999 Feb;140(2):264-7. doi: 10.1046/j.1365-2133.1999.02660.x.

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In vitro and in vivo evaluation of a moisture treatment cream containing three critical elements of natural skin moisturization.一种含有天然皮肤保湿三大关键元素的保湿霜的体外和体内评价。
J Cosmet Dermatol. 2020 May;19(5):1121-1128. doi: 10.1111/jocd.13359. Epub 2020 Mar 6.

本文引用的文献

1
Lipid abnormalities in atopic skin are driven by type 2 cytokines.特应性皮炎皮肤中的脂质异常是由 2 型细胞因子驱动的。
JCI Insight. 2018 Feb 22;3(4). doi: 10.1172/jci.insight.98006.
2
The skin as a target for prevention of the atopic march.皮肤作为预防特应性进行曲的靶标。
Ann Allergy Asthma Immunol. 2018 Feb;120(2):145-151. doi: 10.1016/j.anai.2017.11.023.
3
Atopic dermatitis yardstick: Practical recommendations for an evolving therapeutic landscape.特应性皮炎评估工具：不断发展的治疗领域的实用建议。
Ann Allergy Asthma Immunol. 2018 Jan;120(1):10-22.e2. doi: 10.1016/j.anai.2017.10.039.
4
Skin care products can aggravate epidermal function: studies in a murine model suggest a pathogenic role in sensitive skin.护肤品可加重表皮功能：在一种鼠模型中的研究提示其在敏感性皮肤发病机制中的作用。
Contact Dermatitis. 2018 Feb;78(2):151-158. doi: 10.1111/cod.12909. Epub 2017 Nov 20.
5
Immunologic, microbial, and epithelial interactions in atopic dermatitis.特应性皮炎中的免疫、微生物和上皮相互作用。
Ann Allergy Asthma Immunol. 2018 Jan;120(1):34-41. doi: 10.1016/j.anai.2017.09.055. Epub 2017 Nov 7.
6
A randomized trial of a barrier lipid replacement strategy for the prevention of atopic dermatitis and allergic sensitization: the PEBBLES pilot study.一项用于预防特应性皮炎和过敏致敏的屏障脂质替代策略的随机试验：PEBBLES 初步研究。
Br J Dermatol. 2018 Jan;178(1):e19-e21. doi: 10.1111/bjd.15747. Epub 2017 Dec 1.
7
The how, why and clinical importance of stratum corneum acidification.表皮酸化的方式、原因及临床意义。
Exp Dermatol. 2017 Nov;26(11):999-1003. doi: 10.1111/exd.13329. Epub 2017 May 12.
8
Skin pH Is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model.皮肤 pH 值是 Kallikrein 5 介导的皮肤屏障破坏在小鼠特应性皮炎模型中的主开关。
J Invest Dermatol. 2016 Jan;136(1):127-35. doi: 10.1038/JID.2015.363.
9
Transepidermal water loss measurement during infancy can predict the subsequent development of atopic dermatitis regardless of filaggrin mutations.婴儿期经表皮水分流失测量可预测特应性皮炎的后续发展，无论是否存在丝聚合蛋白突变。
Allergol Int. 2016 Jan;65(1):103-8. doi: 10.1016/j.alit.2015.09.004. Epub 2015 Oct 29.
10
Effect of skin barrier emulsion cream vs a conventional moisturizer on transepidermal water loss and corneometry in atopic dermatitis: a pilot study.皮肤屏障乳霜与传统保湿剂对特应性皮炎经表皮水分流失和角质层含水量的影响：一项初步研究。
J Drugs Dermatol. 2014 Dec;13(12):1482-4.

Does moisturizing the skin equate with barrier repair therapy?

作者信息

Elias Peter M, Sugarman Jeffrey

机构信息

Department of Dermatology, UC San Francisco and VA Medical Center, San Francisco, California.

Associate Clinical Professor, Dermatology and Family Medicine, UC San Francisco, California.

出版信息

Ann Allergy Asthma Immunol. 2018 Dec;121(6):653-656.e2. doi: 10.1016/j.anai.2018.07.008. Epub 2018 Aug 10.

DOI:10.1016/j.anai.2018.07.008
PMID:30009880
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6289688/
Abstract
摘要