Aalto-Korte K
Department of Dermatology, University Central Hospital, Helsinki, Finland.
J Am Acad Dermatol. 1995 Dec;33(6):969-72. doi: 10.1016/0190-9622(95)90288-0.
Active dermatitis causes a disturbance in skin barrier function. This can be evaluated by the measurement of transepidermal water loss (TEWL) and percutaneous absorption of hydrocortisone.
The study objective was to evaluate changes in skin barrier function during treatment of atopic dermatitis.
Nine patients with widespread atopic dermatitis were studied longitudinally by measuring the severity of the dermatitis and TEWL at intervals of 1 to 3 days. Percutaneous absorption of hydrocortisone was measured at entry and during treatment.
At entry, both TEWL and percutaneous absorption of hydrocortisone were elevated. Four to six days later, a significant decline was observed in both variables, indicating rapid improvement in skin barrier function. Individual changes in TEWL correlated with the changes in the systemic absorption of hydrocortisone.
TEWL reflects changes in the systemic absorption of topical hydrocortisone during treatment of atopic dermatitis.
活动性皮炎会导致皮肤屏障功能紊乱。这可通过测量经表皮水分流失（TEWL）和氢化可的松的经皮吸收来评估。
本研究的目的是评估特应性皮炎治疗期间皮肤屏障功能的变化。
对9例广泛性特应性皮炎患者进行纵向研究，每隔1至3天测量皮炎严重程度和TEWL。在入组时和治疗期间测量氢化可的松的经皮吸收。
入组时，TEWL和氢化可的松的经皮吸收均升高。4至6天后，这两个变量均显著下降，表明皮肤屏障功能迅速改善。TEWL的个体变化与氢化可的松全身吸收的变化相关。
TEWL反映了特应性皮炎治疗期间局部氢化可的松全身吸收的变化。
