Jiangsu Key Laboratory of Marine Bioresources and Environment, Huaihai Institute of Technology, 59 Cangwu Road, Haizhou 222005, China; Co-Innovation Center of Jiangsu Marine Bio-industry Technology, 59 Cangwu Road, Haizhou 222005, China; Jiangsu Key Laboratory of Marine Biotechnology, 59 Cangwu Road, Haizhou 222005, China.
Int J Biol Macromol. 2018 Oct 15;118(Pt B):2001-2005. doi: 10.1016/j.ijbiomac.2018.07.082. Epub 2018 Jul 22.
Ganoderma lucidum polysaccharide (GLP) was prepared by hot water extraction and partly characterised by high-performance gel filtration chromatography and its monosaccharide composition. Male Sprague-Dawley rats were randomly divided into four groups: one group received a high-fat diet (control group) and the three other groups received a high-fat diet containing 100, 300 and 500 mg/kg of GLP. GLP administration reduced the body weight gain, food efficiency ratio, levels of plasma triacylglycerol (TG), plasma total cholesterol (TC) and low-density lipoprotein cholesterol and liver weight, TC and TG levels and malondialdehyde values, improved the levels of faecal fat, cholesterol and plasma high-density lipoprotein cholesterol and enhanced the activities of serum superoxide dismutase and glutathione peroxidase in rats compared with the control group. The appropriate dose of GLP was 300 mg/kg. Results indicate that GLP exhibits hypolipidaemic and lipid antioxidant activities and may be used as a drug for hyperlipidaemia treatment.
灵芝多糖（GLP）通过热水提取得到，并通过高效凝胶过滤色谱法及其单糖组成部分进行了部分表征。雄性 Sprague-Dawley 大鼠随机分为四组：一组给予高脂肪饮食（对照组），其余三组给予含有 100、300 和 500mg/kg GLP 的高脂肪饮食。GLP 给药可降低体重增加、食物效率比、血浆三酰甘油（TG）、血浆总胆固醇（TC）和低密度脂蛋白胆固醇以及肝重、TC 和 TG 水平和丙二醛值，提高粪便脂肪、胆固醇和血浆高密度脂蛋白胆固醇水平，并增强血清中超氧化物歧化酶和谷胱甘肽过氧化物酶的活性与对照组相比，大鼠。GLP 的适当剂量为 300mg/kg。结果表明，GLP 具有降血脂和脂质抗氧化活性，可作为治疗高脂血症的药物。
