University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison.
Center for Healthy Minds, University of Wisconsin- Madison.
J Abnorm Psychol. 2018 Jul;127(5):437-447. doi: 10.1037/abn0000355.
Prior research indicates that cognitive vulnerabilities can render individuals more susceptible to psychopathology in the wake of stressful events. However, little work has directly targeted the neural mechanisms involved. In this study, we examined functional magnetic resonance imaging (fMRI) activity as a function of negative cognitive style, a well-studied cognitive vulnerability for depression. We adapted a robust paradigm in which undergraduate students completed fMRI testing after a known ecologically valid stressor (a midterm exam). Negative cognitive style correlated with brain activity in response to both negative and exam-related information in dorsolateral prefrontal cortex and/or angular gyrus, both regions involved in abstract, self-referential thought. There were commonalities and differences in patterns of activity, suggesting that these individuals may process domain-general and domain-specific negative information in different ways but drawing upon a common frontoparietal network. This study, thus, identifies a potential brain network associated with negative cognitive style, and enhances our understanding of neural mechanisms of cognitive vulnerability to psychopathology. (PsycINFO Database Record
先前的研究表明，认知脆弱性可能使个体在面临压力事件后更容易出现精神病理学。然而，很少有工作直接针对涉及的神经机制。在这项研究中，我们检查了功能磁共振成像（fMRI）活动作为负性认知风格的函数，这是一种针对抑郁的研究充分的认知脆弱性。我们改编了一个强大的范式，其中大学生在经历了一个已知的生态有效压力源（期中考试）后完成 fMRI 测试。负性认知风格与背外侧前额叶皮层和/或角回中对负性和考试相关信息的大脑活动相关，这两个区域都参与抽象的、自我参照性思维。活动模式存在共性和差异，这表明这些个体可能以不同的方式处理一般领域和特定领域的负性信息，但都利用了一个共同的额顶叶网络。因此，这项研究确定了一个与负性认知风格相关的潜在大脑网络，增强了我们对认知易感性导致精神病理学的神经机制的理解。（PsycINFO 数据库记录）
