Department of Child and Adolescent Psychiatry, University Hospital Münster, Schmeddingstr. 50, 48149 Münster, Germany.
Institute for Biomagnetism and Biosignalanalysis, University Hospital Münster, Malmedyweg 15, 48149 Münster, Germany.
Neuroimage. 2013 Nov 1;81:15-25. doi: 10.1016/j.neuroimage.2013.04.117. Epub 2013 May 9.
Emotions can be regulated effectively via cognitive change, as evidenced by cognitive behavioural therapy. The neural correlates of cognitive change were investigated using reappraisal, a strategy that involves the reinterpretation of emotional stimuli. Hemodynamic studies revealed cortical structures involved in reappraisal and highlighted the role of the prefrontal cortex in regulating subcortical affective processing. Studies using event-related potentials elucidated the timing of reappraisal by showing effective modulation of the Late Positive Potential (LPP) after 300ms but also even earlier effects. The present study investigated the spatiotemporal dynamics of the cortical network underlying cognitive change via inverse source modelling based on whole-head magnetoencephalography (MEG). During MEG recording, 28 healthy participants saw angry and neutral faces and followed instructions designed to down- or up-regulate emotions via reappraisal. Differences between angry and neutral face processing were specifically enhanced during up-regulation, first in the parietal cortex during M170 and across the whole cortex during LPP-M, with particular involvement of the parietal and dorsal prefrontal cortex regions. Thus, our data suggest that the reappraisal of emotional faces involves specific modulations in a frontoparietal attention network.
情绪可以通过认知改变进行有效调节，认知行为疗法就是明证。本研究采用再评价这一策略，通过重新解释情绪刺激来探究认知改变的神经关联。脑血流研究揭示了再评价所涉及的皮质结构，并强调了前额叶皮层在调节皮质下情感处理中的作用。事件相关电位研究通过显示在 300ms 后晚期正电位（LPP）的有效调节，甚至更早的效应，阐明了再评价的时间进程。本研究通过基于全头脑磁图（MEG）的逆源建模来研究认知改变所涉及的皮质网络的时空动态。在 MEG 记录期间，28 名健康参与者观看了愤怒和中性面孔，并按照通过再评价来下调或上调情绪的指令进行操作。在情绪上调期间，愤怒面孔和中性面孔处理之间的差异特别明显，M170 期间首先在前顶叶皮层，LPP-M 期间则在整个皮层，特别是涉及顶叶和背侧前额叶皮层区域。因此，我们的数据表明，情绪面孔的再评价涉及到一个额顶注意网络的特定调节。
