Zhang Andrew Y, Kargel Jennifer S
Department of Plastic Surgery, University of Texas Southwestern Medical Center, 1801 Inwood Road, Dallas, TX 75390-1932, USA.
Department of Plastic Surgery, University of Texas Southwestern Medical Center, VA North Texas Health Care System, 4500 S. Lancaster Road, Dallas, TX 75216, USA.
Hand Clin. 2018 Aug;34(3):301-305. doi: 10.1016/j.hcl.2018.03.001. Epub 2018 Jun 8.
Dupuytren disease is a fibroproliferative condition affecting the hands of millions of patients worldwide. The hypothesis of pathogenesis involves genetic factors and internal factors. Recent genome-wide association studies have provided much needed evidence for the long-held belief of a strong genetic component to the pathogenesis of Dupuytren disease. Specifically, abnormal activation of the Wnt signaling pathway plays an important role. Regarding internal factors, microvascular angiopathy and ischemia have been shown to lead to activation of transforming growth factor-β1 and proliferation of myofibroblasts.
掌腱膜挛缩症是一种纤维增生性疾病，影响着全球数百万患者的手部。发病机制的假说是涉及遗传因素和内在因素。最近的全基因组关联研究为长期以来认为掌腱膜挛缩症发病机制中存在强大遗传成分的观点提供了急需的证据。具体而言，Wnt信号通路的异常激活起着重要作用。关于内在因素，微血管病变和缺血已被证明会导致转化生长因子-β1的激活和成肌纤维细胞的增殖。
