Werker Paul M N, Degreef Ilse
Department of Plastic Surgery, University Medical Center Groningen, University of Groningen, BB81, Hanzeplein 1, Groningen 9713GZ, the Netherlands.
Department of Orthopedic Surgery-Hand Unit, University Hospitals Leuven, University of Leuven, Herestraat 49, Leuven B-3000, Belgium.
Hand Clin. 2018 Aug;34(3):367-375. doi: 10.1016/j.hcl.2018.03.005. Epub 2018 Jun 8.
Clinicians struggle with limited efficacy and durability of standard treatments when treating patients with Dupuytren disease diathesis. Alternative treatments such as low-dose radiation therapy in early phase of disease, supplemental pharmacotherapy with anti-inflammatory and/or anti-mitotic drugs, as well as other pharmacologic targets, and more aggressive surgery such as dermofasciectomy all have been reported with variable success or with serious side effects that hamper their standard use. This article gives an overview of the available literature.
在治疗患有掌腱膜挛缩症素质的患者时，临床医生在标准治疗的疗效和持久性方面面临挑战。已报道的替代治疗方法，如疾病早期的低剂量放射治疗、使用抗炎和/或抗有丝分裂药物的补充药物治疗以及其他药物靶点，以及更积极的手术如真皮筋膜切除术，都有不同程度的成功或伴有严重副作用，从而妨碍了它们的常规使用。本文对现有文献进行了综述。
