Department of Plastic Surgery, University of Groningen, Groningen, The Netherlands.
Department of Pathology, University of Groningen, Groningen, The Netherlands.
J Hand Surg Eur Vol. 2022 Mar;47(3):280-287. doi: 10.1177/17531934211050214. Epub 2021 Oct 7.
This study aimed to determine the association between the echogenicity of Dupuytren's disease nodules and myofibroblast load, and between echogenicity and nodule hardness. Thirty-eight nodules were assessed sonographically. The echogenicity of nodules was measured objectively with Image J (grey-value) and subjectively by visual inspection (hypo-, mixed and hyper-echogenicity). These findings were compared with myofibroblast load measured by histopathological analysis. In a different cohort, 97 nodules were assessed for grey-value and nodule hardness using a tonometer. There was a moderate, significant, negative association between grey-value and myofibroblast load and the subjective visual measurements corresponded to this finding. There was also a moderate, significant, negative association between grey-value and nodule hardness. Ultrasound and tonometry may be useful in the selection of patients for possible future preventive treatments.
本研究旨在确定 Dupuytren 病结节的回声性与肌成纤维细胞负荷之间，以及回声性与结节硬度之间的关系。对 38 个结节进行了超声评估。使用 Image J（灰度值）对结节的回声性进行客观测量，并通过视觉检查（低回声、混合回声和高回声）进行主观评估。这些发现与组织病理学分析测量的肌成纤维细胞负荷进行了比较。在另一个队列中，使用硬度计对 97 个结节进行了灰度值和结节硬度评估。灰度值与肌成纤维细胞负荷之间存在中度、显著的负相关，主观视觉测量结果与这一发现相符。灰度值与结节硬度之间也存在中度、显著的负相关。超声和硬度计检查可能有助于选择可能需要未来预防治疗的患者。
