Department of Pharmaceutical Chemistry & Quality Assurance, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle (W), Mumbai 400 056, India.
Department of Pharmaceutical Chemistry & Quality Assurance, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle (W), Mumbai 400 056, India.
Int J Pharm. 2018 Sep 5;548(1):707-720. doi: 10.1016/j.ijpharm.2018.07.030. Epub 2018 Jul 21.
Dendrimers are novel polymeric nanoarchitectures characterized by hyper-branched 3D-structure having multiple functional groups on the surface that increases their functionality and make them versatile and biocompatible. Their unique properties like nanoscale uniform size, high degree of branching, polyvalency, water solubility, available internal cavities and convenient synthesis approaches make them promising agent for biological and drug delivery applications. Dendrimers have received an enormous attention from researchers among various nanomaterials. Dendrimers can be used as a carrier for diverse therapeutic agents. They can be used for reducing drug toxicities and enhancement of their efficacies. The present review provide a comprehensive outline of synthesis of dendrimers, interaction of dendrimer with guest molecules, properties, characterization and their potential applications in pharmaceutical and biomedical field.
树状聚合物是一种新型的聚合物纳米结构，具有超支化的 3D 结构，表面具有多个功能基团，这增加了它们的功能，使它们具有多功能性和生物相容性。它们独特的性质，如纳米级均匀的大小、高度的分支、多价性、水溶性、可用的内部空腔和方便的合成方法，使它们成为生物和药物输送应用的有前途的试剂。树状聚合物在各种纳米材料中受到了研究人员的极大关注。树状聚合物可用作多种治疗剂的载体。它们可用于降低药物的毒性并提高其疗效。本综述提供了树状聚合物的合成、树状聚合物与客体分子的相互作用、性质、表征及其在药物和生物医学领域的潜在应用的全面概述。
