树状聚合物：用于药物传递系统的新兴聚合物。

Dendrimers: emerging polymers for drug-delivery systems.

机构信息

Department of Pharmaceutics, JN Medical College, KLE University, Belgaum-590010, India.

出版信息

Eur J Pharm Sci. 2009 Oct 8;38(3):185-96. doi: 10.1016/j.ejps.2009.07.008. Epub 2009 Jul 29.

DOI:10.1016/j.ejps.2009.07.008

PMID:19646528

Abstract

Dendrimers are new class of polymeric materials. It is generally described as a macromolecule, which is characterized by its extensively branched 3D structure that provides a high degree of surface functionality and versatility. The unique properties associated with these dendrimers such as uniform size, high degree of branching, water solubility, multivalency, well-defined molecular weight and available internal cavities make them attractive for biological and drug-delivery applications. Commercialization of dendrimers is now forthcoming. The present review briefly describes about dendrimer synthesis strategies, types of dendrimers with different functionalities, properties which having crucial importance and their potential applications.

摘要

树状聚合物是一类新型的聚合材料。通常将其描述为一种大分子，其特点是具有广泛分支的 3D 结构，提供了高度的表面功能和多功能性。这些树状聚合物具有独特的性质，如均匀的大小、高度的分支、水溶性、多价性、明确的分子量和可用的内部空腔，使它们成为生物和药物输送应用的有吸引力的选择。树状聚合物的商业化即将到来。本文简要描述了树状聚合物的合成策略、具有不同功能的树状聚合物的类型、具有关键重要性的性质及其潜在应用。