Permanently Farnesylated Prelamin A, Progeria, and Atherosclerosis.
作者信息
Worman Howard J, Michaelis Susan
机构信息
Department of Medicine and Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York (H.J.W.).
Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD (S.M.).
出版信息
Circulation. 2018 Jul 17;138(3):283-286. doi: 10.1161/CIRCULATIONAHA.118.034480.
Abstract
摘要
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本文引用的文献
1
Vascular Smooth Muscle-Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome.血管平滑肌特异性早衰蛋白表达加速 Hutchinson-Gilford 早老综合征小鼠模型的动脉粥样硬化和死亡。
Circulation. 2018 Jul 17;138(3):266-282. doi: 10.1161/CIRCULATIONAHA.117.030856. Epub 2018 Feb 28.
2
A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder.前体核纤层蛋白A中一个消除ZMPSTE24切割位点的突变会导致早衰症。
J Cell Sci. 2016 May 15;129(10):1975-80. doi: 10.1242/jcs.187302. Epub 2016 Mar 31.
3
Modulation of LMNA splicing as a strategy to treat prelamin A diseases.调节核纤层蛋白A剪接作为治疗前体核纤层蛋白A疾病的一种策略。
J Clin Invest. 2016 Apr 1;126(4):1592-602. doi: 10.1172/JCI85908. Epub 2016 Mar 21.
4
Biochemistry. A protease for the ages.生物化学。一种历经岁月的蛋白酶。
Science. 2013 Mar 29;339(6127):1529-30. doi: 10.1126/science.1236764.
5
Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity.人类 ZMPSTE24 疾病突变：残留的蛋白水解活性与疾病严重程度相关。
Hum Mol Genet. 2012 Sep 15;21(18):4084-93. doi: 10.1093/hmg/dds233. Epub 2012 Jun 19.
6
Splicing-directed therapy in a new mouse model of human accelerated aging.拼接导向治疗在一种新的人类加速衰老的小鼠模型中。
Sci Transl Med. 2011 Oct 26;3(106):106ra107. doi: 10.1126/scitranslmed.3002847.
7
Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging.亨廷顿病-吉尔福德早衰症的心血管病理学：与衰老血管病理学的相关性。
Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2301-9. doi: 10.1161/ATVBAHA.110.209460. Epub 2010 Aug 26.
8
Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging.原层蛋白 A 可加速平滑肌细胞衰老，是人类血管衰老的新型生物标志物。
Circulation. 2010 May 25;121(20):2200-10. doi: 10.1161/CIRCULATIONAHA.109.902056. Epub 2010 May 10.
9
Laminopathies and the long strange trip from basic cell biology to therapy.核纤层蛋白病以及从基础细胞生物学走向治疗的漫长而奇特之旅。
J Clin Invest. 2009 Jul;119(7):1825-36. doi: 10.1172/JCI37679. Epub 2009 Jul 1.
10
Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration.血管平滑肌细胞的慢性凋亡会加速动脉粥样硬化，并促进钙化和中膜退变。
Circ Res. 2008 Jun 20;102(12):1529-38. doi: 10.1161/CIRCRESAHA.108.175976. Epub 2008 May 22.
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