School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China.
College of Athletic Performance, Shanghai University of Sport, Shanghai 200438, China.
Zool Res. 2024 Jul 18;45(4):724-746. doi: 10.24272/j.issn.2095-8137.2023.397.
Aging is an inevitable physiological process, often accompanied by age-related bone loss and subsequent bone-related diseases that pose serious health risks. Research on skeletal diseases caused by aging in humans is challenging due to lengthy study durations, difficulties in sampling, regional variability, and substantial investment. Consequently, mice are preferred for such studies due to their similar motor system structure and function to humans, ease of handling and care, low cost, and short generation time. In this review, we present a comprehensive overview of the characteristics, limitations, applicability, bone phenotypes, and treatment methods in naturally aging mice and prematurely aging mouse models (including , mutant, , , , , , , and -deficient mice). We also summarize the molecular mechanisms of these aging mouse models, including cellular DNA damage response, senescence-related secretory phenotype, telomere shortening, oxidative stress, bone marrow mesenchymal stem cell (BMSC) abnormalities, and mitochondrial dysfunction. Overall, this review aims to enhance our understanding of the pathogenesis of aging-related bone diseases.
衰老是一个不可避免的生理过程，常伴随着与年龄相关的骨质流失和随后的骨骼相关疾病，这些疾病对健康构成严重威胁。由于研究周期长、采样困难、地域差异大和投资巨大，人类衰老引起的骨骼疾病的研究具有挑战性。因此，由于其运动系统结构和功能与人类相似、易于处理和护理、成本低以及世代时间短，老鼠成为此类研究的首选。在这篇综述中，我们全面介绍了自然衰老和早衰小鼠模型（包括、、、、、、、和 - 缺陷小鼠）的特征、局限性、适用性、骨表型和治疗方法。我们还总结了这些衰老小鼠模型的分子机制，包括细胞 DNA 损伤反应、衰老相关分泌表型、端粒缩短、氧化应激、骨髓间充质干细胞（BMSC）异常和线粒体功能障碍。总的来说，这篇综述旨在增强我们对与衰老相关的骨骼疾病发病机制的理解。
