氨溴索诱导自噬并增强利福平抗分枝杆菌活性。
Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity.
机构信息
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
出版信息
Antimicrob Agents Chemother. 2018 Aug 27;62(9). doi: 10.1128/AAC.01019-18. Print 2018 Sep.
Abstract
Host-directed therapy in tuberculosis is a potential adjunct to antibiotic chemotherapy directed at Ambroxol, a lead compound, emerged from a screen for autophagy-inducing drugs. At clinically relevant doses, ambroxol induced autophagy and and promoted mycobacterial killing in macrophages. Ambroxol also potentiated rifampin activity in a murine tuberculosis model.
摘要
结核分枝杆菌宿主导向治疗是抗生素化学治疗的一种潜在辅助手段，针对的是从自噬诱导药物筛选中脱颖而出的先导化合物氨溴索。在临床相关剂量下，氨溴索诱导自噬，并促进巨噬细胞中分枝杆菌的杀伤。氨溴索还增强了利福平在小鼠结核模型中的活性。
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