克拉霉素和吡嗪酰胺对人巨噬细胞内结核分枝杆菌的协同活性。
Synergistic activities of clarithromycin and pyrazinamide against Mycobacterium tuberculosis in human macrophages.
作者信息
Mor N, Esfandiari A
机构信息
Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA.
出版信息
Antimicrob Agents Chemother. 1997 Sep;41(9):2035-6. doi: 10.1128/AAC.41.9.2035.
Abstract
The combination of clarithromycin and pyrazinamide was found to be synergistic against Mycobacterium tuberculosis in human macrophages. MICs were four- to eightfold lower for this combination than they were for either drug alone. Clarithromycin and rifampin, however, had only an additive effect.
摘要
在人类巨噬细胞中，发现克拉霉素和吡嗪酰胺联合使用对结核分枝杆菌具有协同作用。该联合用药的最低抑菌浓度（MIC）比单独使用任何一种药物时低四至八倍。然而，克拉霉素和利福平仅具有相加作用。
相似文献
1
Synergistic activities of clarithromycin and pyrazinamide against Mycobacterium tuberculosis in human macrophages.
Antimicrob Agents Chemother. 1997 Sep;41(9):2035-6. doi: 10.1128/AAC.41.9.2035.
2
Antituberculosis activity of clarithromycin.
Antimicrob Agents Chemother. 1995 Dec;39(12):2692-5. doi: 10.1128/AAC.39.12.2692.
3
In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages.
Curr Microbiol. 1996 Sep;33(3):167-75. doi: 10.1007/s002849900095.
4
Determination of in vitro synergy when three antimicrobial agents are combined against Mycobacterium tuberculosis.
Int J Antimicrob Agents. 2005 Oct;26(4):292-7. doi: 10.1016/j.ijantimicag.2005.05.005.
5
Synergistic activities of clarithromycin and antituberculous drugs against multidrug-resistant Mycobacterium tuberculosis.
Antimicrob Agents Chemother. 1995 Jul;39(7):1542-5. doi: 10.1128/AAC.39.7.1542.
6
The molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosis.
Respir Res. 2001;2(3):164-8. doi: 10.1186/rr54. Epub 2001 Apr 5.
7
[Bactericidal therapy in patients with tuberculosis].
Probl Tuberk Bolezn Legk. 2004(3):21-6.
8
The Combination Rifampin-Nitazoxanide, but Not Rifampin-Isoniazid-Pyrazinamide-Ethambutol, Kills Dormant Mycobacterium tuberculosis in Hypoxia at Neutral pH.
Antimicrob Agents Chemother. 2019 Jun 24;63(7). doi: 10.1128/AAC.00273-19. Print 2019 Jul.
9
Characterizing the Effects of Glutathione as an Immunoadjuvant in the Treatment of Tuberculosis.
Antimicrob Agents Chemother. 2018 Oct 24;62(11). doi: 10.1128/AAC.01132-18. Print 2018 Nov.
引用本文的文献
1
Tuberculosis chemotherapy: current drug delivery approaches.
Respir Res. 2006 Sep 19;7(1):118. doi: 10.1186/1465-9921-7-118.
2
Drug treatment for tuberculosis during pregnancy: safety considerations.
Drug Saf. 2001;24(7):553-65. doi: 10.2165/00002018-200124070-00006.
3
Genetics and pulmonary medicine. 5. Genetics of drug resistant tuberculosis.
Thorax. 1998 Sep;53(9):793-7. doi: 10.1136/thx.53.9.793.
本文引用的文献
1
Combined effect of pyrazinamide and ofloxacin within the human macrophage.
Tuber Lung Dis. 1996 Dec;77(6):491-5. doi: 10.1016/s0962-8479(96)90045-3.
2
Clarithromycin is inactive against Mycobacterium tuberculosis.
Antimicrob Agents Chemother. 1995 Dec;39(12):2827-8. doi: 10.1128/AAC.39.12.2827.
3
Treatment of tuberculosis and tuberculosis infection in adults and children. American Thoracic Society and The Centers for Disease Control and Prevention.
Am J Respir Crit Care Med. 1994 May;149(5):1359-74. doi: 10.1164/ajrccm.149.5.8173779.
4
Synergistic activities of clarithromycin and antituberculous drugs against multidrug-resistant Mycobacterium tuberculosis.
Antimicrob Agents Chemother. 1995 Jul;39(7):1542-5. doi: 10.1128/AAC.39.7.1542.
5
Controlled chemoprophylaxis trials in tuberculosis. A general review.
Bibl Tuberc. 1970;26:28-106.
6
Pyrazinamide susceptibility and amidase activity of tubercle bacilli.
Am Rev Respir Dis. 1967 Mar;95(3):461-9. doi: 10.1164/arrd.1967.95.3.461.
7
Inhibition by pyrazinamide of tubercle bacilli within cultured human macrophages.
Am Rev Respir Dis. 1986 Nov;134(5):1052-5. doi: 10.1164/arrd.1986.134.5.1052.
8
In vitro and in vivo activities of clarithromycin against Mycobacterium avium.
Antimicrob Agents Chemother. 1989 Sep;33(9):1531-4. doi: 10.1128/AAC.33.9.1531.
9
Comparative antimycobacterial activities of difloxacin, temafloxacin, enoxacin, pefloxacin, reference fluoroquinolones, and a new macrolide, clarithromycin.
Antimicrob Agents Chemother. 1989 Apr;33(4):591-2. doi: 10.1128/AAC.33.4.591.
10
Pyrazinamide and pyrazinoic acid activity against tubercle bacilli in cultured human macrophages and in the BACTEC system.
J Infect Dis. 1990 Jul;162(1):201-7. doi: 10.1093/infdis/162.1.201.
Zotero 插件