克拉霉素和吡嗪酰胺对人巨噬细胞内结核分枝杆菌的协同活性。
Synergistic activities of clarithromycin and pyrazinamide against Mycobacterium tuberculosis in human macrophages.
作者信息
Mor N, Esfandiari A
机构信息
Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA.
出版信息
Antimicrob Agents Chemother. 1997 Sep;41(9):2035-6. doi: 10.1128/AAC.41.9.2035.
Abstract
The combination of clarithromycin and pyrazinamide was found to be synergistic against Mycobacterium tuberculosis in human macrophages. MICs were four- to eightfold lower for this combination than they were for either drug alone. Clarithromycin and rifampin, however, had only an additive effect.
摘要
在人类巨噬细胞中，发现克拉霉素和吡嗪酰胺联合使用对结核分枝杆菌具有协同作用。该联合用药的最低抑菌浓度（MIC）比单独使用任何一种药物时低四至八倍。然而，克拉霉素和利福平仅具有相加作用。
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