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The yeast alpha-factor receptor: structural properties deduced from the sequence of the STE2 gene.酵母α-因子受体：从STE2基因序列推导的结构特性
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2
Multiple regulation of STE2, a mating-type-specific gene of Saccharomyces cerevisiae.酿酒酵母交配型特异性基因STE2的多重调控
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Functional domains of a peptide hormone receptor: the alpha-factor receptor (STE2 gene product) of the yeast Saccharomyces cerevisiae.一种肽类激素受体的功能结构域：酿酒酵母的α-因子受体（STE2基因产物）
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本文引用的文献

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A simple method for displaying the hydropathic character of a protein.一种展示蛋白质亲水性特征的简单方法。
J Mol Biol. 1982 May 5;157(1):105-32. doi: 10.1016/0022-2836(82)90515-0.
2
Nucleotide sequence comparisons and functional analysis of yeast centromere DNAs.酵母着丝粒DNA的核苷酸序列比较与功能分析。
Cell. 1982 May;29(1):235-44. doi: 10.1016/0092-8674(82)90108-8.
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Transfer of proteins across membranes.蛋白质跨膜转运
Annu Rev Biochem. 1981;50:317-48. doi: 10.1146/annurev.bi.50.070181.001533.
4
Cloning of yeast gene for trichodermin resistance and ribosomal protein L3.抗木霉菌素酵母基因与核糖体蛋白L3的克隆
Proc Natl Acad Sci U S A. 1981 Jan;78(1):238-42. doi: 10.1073/pnas.78.1.238.
5
Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone.对多肽交配激素的细胞分裂控制无反应的酿酒酵母突变体。
J Cell Biol. 1980 Jun;85(3):811-22. doi: 10.1083/jcb.85.3.811.
6
Biochemistry of sensing and adaptation in a simple bacterial system.简单细菌系统中的传感与适应生物化学
Annu Rev Biochem. 1981;50:765-82. doi: 10.1146/annurev.bi.50.070181.004001.
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Organization and expression of eucaryotic split genes coding for proteins.编码蛋白质的真核生物断裂基因的组织与表达。
Annu Rev Biochem. 1981;50:349-83. doi: 10.1146/annurev.bi.50.070181.002025.
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Rhodopsin and bacteriorhodopsin: structure-function relationships.视紫红质与细菌视紫红质：结构-功能关系
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Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.真核生物mRNA翻译起始位点上游序列的汇编与分析。
Nucleic Acids Res. 1984 Jan 25;12(2):857-72. doi: 10.1093/nar/12.2.857.
10
Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.缓冲液梯度凝胶和35S标记辅助快速DNA序列测定。
Proc Natl Acad Sci U S A. 1983 Jul;80(13):3963-5. doi: 10.1073/pnas.80.13.3963.

酵母α-因子受体：从STE2基因序列推导的结构特性

The yeast alpha-factor receptor: structural properties deduced from the sequence of the STE2 gene.

作者信息

Burkholder A C, Hartwell L H

出版信息

Nucleic Acids Res. 1985 Dec 9;13(23):8463-75. doi: 10.1093/nar/13.23.8463.

DOI:10.1093/nar/13.23.8463
PMID:3001640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC322145/
Abstract

The STE2 gene of the yeast Saccharomyces cerevisiae encodes a component of the receptor for the oligopeptide pheromone alpha-factor. We have cloned and determined the nucleotide sequence of the STE2 gene. A sequence involved in the control of cell-type expression of the STE2 gene was found 5' of an open reading frame that could encode a protein of 431 amino acids. The predicted STE2 protein contains seven hydrophobic segments, suggesting that the alpha-factor receptor is an integral membrane protein. No extensive homology at the primary sequence level was detected between the predicted STE2 protein and other available protein sequences.

摘要

酿酒酵母的STE2基因编码寡肽信息素α-因子受体的一个组分。我们已克隆并测定了STE2基因的核苷酸序列。在一个可读框5'端发现了一个参与STE2基因细胞类型表达调控的序列，该可读框可编码一个含431个氨基酸的蛋白质。预测的STE2蛋白含有7个疏水片段，这表明α-因子受体是一种整合膜蛋白。在预测的STE2蛋白与其他已知蛋白质序列之间未检测到一级序列水平的广泛同源性。