Sandra and Edward Meyer Cancer Center, Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10021, USA.
Sandra and Edward Meyer Cancer Center, Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10021, USA; Department of Biochemistry, Weill Cornell Medicine, New York, NY 10021, USA.
Trends Mol Med. 2018 Sep;24(9):731-733. doi: 10.1016/j.molmed.2018.06.010. Epub 2018 Jul 17.
Two recent reports show that, in some contexts, CRISPR-mediated genome editing can lead to a p53-mediated stress response and cell-cycle arrest. These findings may help to explain why CRISPR-mediated genetic manipulation in different cell types leads to dissimilar outcomes, and highlights the need for a better understanding of the factors that influence effective genome editing in vitro and in vivo.
最近的两份报告显示，在某些情况下，CRISPR 介导的基因组编辑会导致 p53 介导的应激反应和细胞周期停滞。这些发现可能有助于解释为什么 CRISPR 介导的不同细胞类型中的遗传操作会导致不同的结果，并强调了需要更好地理解影响体外和体内有效基因组编辑的因素。
