Dzidic Majda, Boix-Amorós Alba, Selma-Royo Marta, Mira Alex, Collado Maria Carmen
Department of Biotechnology, Institute of Agrochemistry and Food Technology-Spanish National Research Council (IATA-CSIC), 46980 Valencia, Spain.
Department of Health and Genomics. Center for Advanced Research in Public Health, FISABIO Foundation, 46020 Valencia, Spain.
Med Sci (Basel). 2018 Jul 17;6(3):56. doi: 10.3390/medsci6030056.
Gut microbiota colonization is a complex, dynamic, and step-wise process that is in constant development during the first years of life. This microbial settlement occurs in parallel with the maturation of the immune system, and alterations during this period, due to environmental and host factors, are considered to be potential determinants of health-outcomes later in life. Given that host⁻microbe interactions are mediated by the immune system response, it is important to understand the close relationship between immunity and the microbiota during birth, lactation, and early infancy. This work summarizes the evidence to date on early gut microbiota colonization, and how it influences the maturation of the infant immune system and health during the first 1000 days of life. This review will also address the influence of perinatal antibiotic intake and the importance of delivery mode and breastfeeding for an appropriate development of gut immunity.
肠道微生物群定殖是一个复杂、动态且分阶段的过程，在生命的最初几年中不断发展。这种微生物的定居与免疫系统的成熟同时发生，由于环境和宿主因素，这一时期的变化被认为是日后健康结果的潜在决定因素。鉴于宿主与微生物的相互作用是由免疫系统反应介导的，了解出生、哺乳和婴儿早期免疫与微生物群之间的密切关系非常重要。这项工作总结了迄今为止关于早期肠道微生物群定殖的证据，以及它如何影响生命最初1000天内婴儿免疫系统的成熟和健康。本综述还将探讨围产期抗生素摄入的影响以及分娩方式和母乳喂养对肠道免疫正常发育的重要性。
