Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsmedizin Rostock, 18147, Rostock, Germany.
Department of Psychiatry and Psychotherapy, Charité-University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Eur Arch Psychiatry Clin Neurosci. 2018 Dec;268(8):861-864. doi: 10.1007/s00406-018-0924-0. Epub 2018 Jul 17.
Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2 mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged the start latency in the elevated O-Maze test, an effect that was abolished in Tph2 mice. Furthermore, in the absence of 5-HT, the ECS-induced increase in adult neurogenesis and in brain-derived neurotrophic factor signaling in the hippocampus were significantly reduced. Our results indicate that brain 5-HT critically contributes to the neurobiological responses to ECS.
靶向 5-羟色胺（5-HT）的化合物被广泛用作抗抑郁药。然而，5-HT 在介导电惊厥治疗（ECT）的效果中的作用仍未被定义。使用 Tph2 小鼠脑内 5-HT 耗竭，我们研究了 ECS 对行为和神经生物学的影响。ECT 显著延长了高架 O-迷宫测试中的起始潜伏期，而在 Tph2 小鼠中这种作用被消除。此外，在缺乏 5-HT 的情况下，ECT 诱导的海马内成年神经发生和脑源性神经营养因子信号的增加明显减少。我们的结果表明，脑内 5-HT 对 ECS 的神经生物学反应有重要贡献。
