Oyejide A, Moulton J E, Wolcott J A
Vet Immunol Immunopathol. 1985 Nov;10(2-3):253-63. doi: 10.1016/0165-2427(85)90051-0.
The effects of Trypanosoma equiperdum infections on the immunological and pathological responses of deer mice (Peromyscus maniculatus) to influenza virus exposure were investigated. Mice carrying a 5 week trypanosome infection along with an age- and sex-matched trypanosome-free control group were simultaneously exposed to influenza Ao (WSN) virus. T. equiperdum infection significantly (P less than 0.01) converted a sub-lethal virus attack into a fatal pneumonic process in a small proportion of animals. In addition, the trypanosome caused a reduction (p less than 0.1) in virus replication on PID 1 and 2, accompanied later by a tendency towards virus persistence in the lungs of affected mice. This tendency was manifested by a log reduction in virus titres between PID 2 and 4 and PID 4 and 6 in the lungs of trypanosome-infected mice, compared to 2 log drops over the same periods in the lungs of control mice. T. equiperdum infection also significantly (p less than 0.001) depressed serum and pulmonary neutralizing antibody titres to influenza virus.
研究了马媾疫锥虫感染对鹿鼠（白足鼠）感染流感病毒后的免疫和病理反应的影响。携带5周锥虫感染的小鼠以及年龄和性别匹配的无锥虫对照组小鼠同时暴露于甲型流感（WSN）病毒。马媾疫锥虫感染在一小部分动物中显著（P小于0.01）将亚致死性病毒攻击转变为致命的肺炎过程。此外，锥虫在感染后第1天和第2天导致病毒复制减少（p小于0.1），随后受感染小鼠肺部出现病毒持续存在的趋势。与对照小鼠肺部在相同时间段内2个对数级的下降相比，感染马媾疫锥虫的小鼠肺部在感染后第2天至第4天以及第4天至第6天病毒滴度对数下降，体现了这种趋势。马媾疫锥虫感染还显著（p小于0.001）降低了血清和肺部针对流感病毒的中和抗体滴度。
