Moulton J E, Coleman J L
Am J Vet Res. 1977 May;38(5):573-9.
Light and electron microscopic examinations of deer mice (Peromyscus maniculatus) chronically infected with Trypanosoma equiperdum revealed hyperplasia of germinal center lymphocytes (germanocytes) in the lymph follicles of spleen and lymph nodes and infiltration of the splenic red pulp cords and nodal medullary cords with plasma cells. Proliferation and infiltration of plasma cells caused disruption of the B- and T-lymphocyte areas in these organs. Stimulation of splenic lymphocytes in vitro by phytohemagglutinin and concanavalin A revealed marked depression in T-lymphocyte response; stimulation with lipopolysaccharide and pokeweed mitogens showed depression of B-cell response. Deer mice infected with virulent trypanosomes had decreased immunologic response to injection of sheep red blood cells, whereas deer mice given radioattenuated trypanosomes had normal to enhanced immunologic response to injection of sheep red blood cells.
对长期感染马媾疫锥虫的鹿鼠（白足鼠）进行光镜和电镜检查发现，脾脏和淋巴结淋巴滤泡中生发中心淋巴细胞（生殖细胞）增生，脾红髓索和淋巴结髓索中有浆细胞浸润。浆细胞的增殖和浸润导致这些器官中B淋巴细胞区和T淋巴细胞区遭到破坏。用植物血凝素和刀豆球蛋白A在体外刺激脾淋巴细胞，结果显示T淋巴细胞反应明显受抑；用脂多糖和商陆丝裂原刺激则显示B细胞反应受抑。感染强毒锥虫的鹿鼠对注射绵羊红细胞的免疫反应降低，而接种减毒锥虫的鹿鼠对注射绵羊红细胞的免疫反应正常或增强。
