Cata Juan P
Department of Anesthesiology and Perioperative Medicine, The University of Texas -MD Anderson Cancer Center; Anesthesia and Surgical Oncology Research Group, Houston, Texas, USA.
Curr Opin Anaesthesiol. 2018 Oct;31(5):593-600. doi: 10.1097/ACO.0000000000000636.
To summarize the current evidence on the impact of regional anesthesia or analgesia on cancer recurrence.
Preclinical investigations suggest that regional anesthesia could have a positive impact on reducing cancer growth and progression. Regional anesthesia is also associated with better immunological and stress-related outcomes in patients undergoing major oncological surgery. Most recent retrospective studies do not show any benefit of regional anesthesia or analgesia on cancer recurrence or recurrence-free survival.
The available clinical evidence does not support the use of any anesthesia technique to improve the cancer-related survival after major oncological surgery. The results from four randomized controlled trials will shed light on this critical topic in perioperative medicine.
总结目前关于区域麻醉或镇痛对癌症复发影响的证据。
临床前研究表明，区域麻醉可能对减少癌症生长和进展有积极影响。区域麻醉还与接受大型肿瘤手术患者更好的免疫和应激相关结果相关。最近的回顾性研究未显示区域麻醉或镇痛对癌症复发或无复发生存有任何益处。
现有的临床证据不支持使用任何麻醉技术来改善大型肿瘤手术后的癌症相关生存率。四项随机对照试验的结果将为围手术期医学中的这一关键问题提供线索。
