Department of Immunology, Duke University, Durham, NC, USA.
Department of Immunology, Duke University, Durham, NC, USA; Department of Pediatrics, Duke University, Durham, NC, USA; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.
Immunity. 2018 Jul 17;49(1):6-8. doi: 10.1016/j.immuni.2018.06.013.
In this issue of Immunity, Šestan et al. (2018) show that viral-induced inflammation leads to insulin resistance in skeletal muscle, followed by compensatory hyperinsulinemia, which promotes the anti-viral effector response of CD8 T cells. Interestingly, this leads to persistent glucose intolerance and the progression of type 2 diabetes in pre-diabetic animals.
在本期《免疫》中，Šestan 等人（2018 年）表明，病毒诱导的炎症会导致骨骼肌胰岛素抵抗，随后出现代偿性高胰岛素血症，从而促进 CD8 T 细胞的抗病毒效应反应。有趣的是，这会导致糖尿病前期动物持续的葡萄糖不耐受和 2 型糖尿病的进展。
