Katipoglu Bilal, Naharci Mehmet Ilkin, Yurdakul Eray Serdar
Gulhane Faculty of Medicine & Gulhane Training and Research Hospital, Division of Geriatrics, University of Health Sciences, 06010 Ankara, Turkey.
Gulhane Faculty of Medicine & Gulhane Training and Research Hospital, Department of Internal Medicine, University of Health Sciences, 06010 Ankara, Turkey.
J Diabetes Metab Disord. 2022 Jul 7;21(2):1443-1449. doi: 10.1007/s40200-022-01078-0. eCollection 2022 Dec.
Patients with Covid-19 disease could present with flu-like symptoms. However, nearly half of the subjects with positive test results for Covid-19 remain asymptomatic. Data on factors related to the duration of hospital stay in Covid-19 patients with diabetes mellitus remain limited.
We aimed to identify risk factors predicting prolonged hospital length of stay (LOS) among diabetic patients hospitalized with Covid-19.
This cohort study involved patients with type 2 diabetes (T2D) admitted to a tertiary hospital with mild or moderate Covid-19 between August 1 and November 31, 2020. Data on demographics, laboratory parameters, and clinical treatments were extracted from the medical records. Prolonged LOS was defined as equal to or greater than the median hospitable stay time. We used univariate and multivariate logistic regression analyses to explore risk factors associated with LOS.
We included 87 hospitalized T2D patients with mild or moderate Covid-19. The mean age was 69.5 ± 6.9 years, and 59.8% were female. In the unadjusted analysis, factors influencing the length of hospitalization were as follows: undertreatment of diabetes, high procalcitonin level, glycated hemoglobin, and low lymphocyte count. After adjustment for all covariates, subjects with a low lymphocyte had a 3.9 fold increased risk of prolonged LOS (OR:3.925 CI:1.044-14.755 p = 0.043).
A lower lymphocyte count on admission was associated with prolonged hospital LOS in older T2D patients with Covid-19, suggesting this marker could help clinicians predict complications for an adverse outcome.
新冠肺炎患者可能出现流感样症状。然而，近一半新冠病毒检测呈阳性的受试者无症状。关于糖尿病合并新冠肺炎患者住院时间相关因素的数据仍然有限。
我们旨在确定预测新冠病毒感染住院糖尿病患者住院时间延长的危险因素。
这项队列研究纳入了2020年8月1日至11月31日期间因轻度或中度新冠肺炎入住三级医院的2型糖尿病（T2D）患者。从病历中提取人口统计学、实验室参数和临床治疗数据。住院时间延长定义为等于或大于中位住院时间。我们使用单因素和多因素逻辑回归分析来探讨与住院时间相关的危险因素。
我们纳入了87例轻度或中度新冠肺炎住院的T2D患者。平均年龄为69.5±6.9岁，59.8%为女性。在未调整分析中，影响住院时间的因素如下：糖尿病治疗不足、降钙素原水平高、糖化血红蛋白和淋巴细胞计数低。在对所有协变量进行调整后，淋巴细胞计数低的受试者住院时间延长的风险增加3.9倍（OR：3.925，CI：1.044 - 14.755，p = 0.043）。
入院时淋巴细胞计数较低与老年新冠病毒感染T2D患者住院时间延长有关，表明该指标可帮助临床医生预测不良结局的并发症。
