Wang Kaiqin, Jiang Hui, Li Wenshuang, Qiang Mingyue, Dong Tianxiang, Li Hongbin
Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Front Physiol. 2018 Jul 4;9:819. doi: 10.3389/fphys.2018.00819. eCollection 2018.
Vitamin C (ascorbic acid) plays an important role in maintaining skin health and can promote the differentiation of keratinocytes and decrease melanin synthesis, leading to antioxidant protection against UV-induced photodamage. Normal skin needs high concentrations of vitamin C, which plays many roles in the skin, including the formation of the skin barrier and collagen in the dermis, the ability to counteract skin oxidation, and the modulation of cell signal pathways of cell growth and differentiation. However, vitamin C deficiency can cause or aggravate the occurrence and development of some skin diseases, such as atopic dermatitis (AD) and porphyria cutanea tarda (PCT). Levels of vitamin C in plasma are decreased in AD, and vitamin C deficiency may be one of the factors that contributes to the pathogenesis of PCT. On the other hand, high doses of vitamin C have significantly reduced cancer cell viability, as well as invasiveness, and induced apoptosis in human malignant melanoma. In this review, we will summarize the effects of vitamin C on four skin diseases (porphyria cutanea tarda, atopic dermatitis, malignant melanoma, and herpes zoster and postherpetic neuralgia) and highlight the potential of vitamin C as a therapeutic strategy to treat these diseases, emphasizing the clinical application of vitamin C as an adjuvant for drugs or physical therapy in other skin diseases.
维生素C（抗坏血酸）在维持皮肤健康方面发挥着重要作用，可促进角质形成细胞的分化并减少黑色素合成，从而提供抗氧化保护，抵御紫外线引起的光损伤。正常皮肤需要高浓度的维生素C，它在皮肤中发挥多种作用，包括形成皮肤屏障和真皮中的胶原蛋白、抵抗皮肤氧化的能力以及调节细胞生长和分化的细胞信号通路。然而，维生素C缺乏会导致或加重某些皮肤疾病的发生和发展，如特应性皮炎（AD）和迟发性皮肤卟啉病（PCT）。AD患者血浆中的维生素C水平会降低，维生素C缺乏可能是导致PCT发病机制的因素之一。另一方面，高剂量的维生素C可显著降低癌细胞的活力和侵袭性，并诱导人恶性黑色素瘤细胞凋亡。在本综述中，我们将总结维生素C对四种皮肤疾病（迟发性皮肤卟啉病、特应性皮炎、恶性黑色素瘤以及带状疱疹和带状疱疹后神经痛）的影响，并强调维生素C作为治疗这些疾病的潜在治疗策略，着重介绍维生素C作为其他皮肤疾病药物或物理治疗辅助剂的临床应用。
