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用于表面增强拉曼散射成像和光动力治疗的叶酸受体靶向诊疗纳米结构体

Folate Receptor-Targeted Theranostic Nanoconstruct for Surface-Enhanced Raman Scattering Imaging and Photodynamic Therapy.

作者信息

Fales Andrew M, Crawford Bridget M, Vo-Dinh Tuan

机构信息

Fitzpatrick Institute for Photonics, Department of Biomedical Engineering, and Department of Chemistry, Duke University, 101 Science Drive, Box 90281, Durham, North Carolina 27708, United States.

出版信息

ACS Omega. 2016 Oct 31;1(4):730-735. doi: 10.1021/acsomega.6b00176.

DOI:10.1021/acsomega.6b00176
PMID:30023488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6044700/
Abstract

We report the synthesis of a folate receptor (FR)-targeted theranostic nanocomposite for surface-enhanced Raman scattering (SERS) imaging and photodynamic therapy (PDT). FR-specific SERS detection and PDT are demonstrated in vitro using two FR-positive cancer cell lines and one FR-negative cancer cell lines.

摘要

我们报道了一种用于表面增强拉曼散射（SERS）成像和光动力疗法（PDT）的叶酸受体（FR）靶向治疗诊断纳米复合材料的合成。使用两种FR阳性癌细胞系和一种FR阴性癌细胞系在体外证明了FR特异性SERS检测和PDT。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4d/6643363/39725d88cc51/ao-2016-00176q_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4d/6643363/07021001e907/ao-2016-00176q_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4d/6643363/80608704d265/ao-2016-00176q_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4d/6643363/9591f09b244d/ao-2016-00176q_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4d/6643363/39725d88cc51/ao-2016-00176q_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4d/6643363/07021001e907/ao-2016-00176q_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4d/6643363/80608704d265/ao-2016-00176q_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4d/6643363/9591f09b244d/ao-2016-00176q_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4d/6643363/39725d88cc51/ao-2016-00176q_0002.jpg

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