Duong Hau Van, Chau Trang The Lieu, Dang Nhan Thi Thanh, Vanterpool Frankie, Salmerón-Sánchez Manuel, Lizundia Erlantz, Tran Hoa Thai, Nguyen Long Viet, Nguyen Thanh-Dinh
Department of Chemistry, Hue University of Sciences, Hue University, 77 Nguyen Hue, Hue 530000, Vietnam.
Department of Chemistry, Hue University of Agriculture and Forestry, Hue University, 102 Phung Hung, Hue 530000, Vietnam.
ACS Omega. 2018 Jan 31;3(1):86-95. doi: 10.1021/acsomega.7b01355. Epub 2018 Jan 4.
Simultaneous integration of photon emission and biocompatibility into nanoparticles is an interesting strategy to develop applications of advanced optical materials. In this work, we present the synthesis of biocompatible optical nanocomposites from the combination of near-infrared luminescent lanthanide nanoparticles and water-soluble chitosan. NaYF:Yb,Er upconverting nanocrystal guests and water-soluble chitosan hosts are prepared and integrated together into biofunctional optical composites. The control of aqueous dissolution, gelation, assembly, and drying of NaYF:Yb,Er nanocolloids and chitosan liquids allowed us to design novel optical structures of spongelike aerogels and beadlike microspheres. Well-defined shape and near-infrared response lead upconverting nanocrystals to serve as photon converters to couple with plasmonic gold (Au) nanoparticles. Biocompatible chitosan-stabilized Au/NaYF:Yb,Er nanocomposites are prepared to show their potential use in biomedicine as we find them exhibiting a half-maximal effective concentration (EC) of 0.58 mg mL for chitosan-stabilized Au/NaYF:Yb,Er nanorods versus 0.24 mg mL for chitosan-stabilized NaYF:Yb,Er after 24 h. As a result of their low cytotoxicity and upconverting response, these novel materials hold promise to be interesting for biomedicine, analytical sensing, and other applications.
将光子发射和生物相容性同时整合到纳米颗粒中是开发先进光学材料应用的一个有趣策略。在这项工作中，我们展示了由近红外发光镧系纳米颗粒与水溶性壳聚糖相结合合成生物相容性光学纳米复合材料。制备了NaYF:Yb,Er上转换纳米晶客体和水溶性壳聚糖主体，并将它们整合在一起形成生物功能光学复合材料。对NaYF:Yb,Er纳米胶体和壳聚糖液体的水相溶解、凝胶化、组装和干燥过程的控制，使我们能够设计出新型的海绵状气凝胶和珠状微球光学结构。形状明确且具有近红外响应的上转换纳米晶可作为光子转换器与等离子体金（Au）纳米颗粒耦合。制备了生物相容性壳聚糖稳定的Au/NaYF:Yb,Er纳米复合材料，以展示其在生物医学中的潜在用途，因为我们发现壳聚糖稳定的Au/NaYF:Yb,Er纳米棒在24小时后的半数有效浓度（EC50）为0.58 mg/mL，而壳聚糖稳定的NaYF:Yb,Er为0.24 mg/mL。由于其低细胞毒性和上转换响应，这些新型材料有望在生物医学、分析传感及其他应用中展现出吸引力。
