Biswas Arnab, Mukhopadhyay Sujay, Singh Roop Shikha, Kumar Ashish, Rana Nishant Kumar, Koch Biplob, Pandey Daya Shankar
Department of Chemistry, Institute of Science, and Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi 221 005, Uttar Pradesh, India.
ACS Omega. 2018 May 31;3(5):5417-5425. doi: 10.1021/acsomega.7b01837. Epub 2018 May 21.
Manipulating gelation properties of the isomeric zinc-terpyridine complexes C-1 (nongelator) and C-2 (gelator) using three different luminescent dyes, viz., acridine yellow (AY), ethidium bromide (EB), and azido-boron dipyrromethene, have been described. Hybrid gels created by the combination of C-1, C-2, and above-mentioned dyes have been termed complex-luminogen mixed gels (CLMGs). Ensuing CLMGs have been thoroughly characterized by spectral, morphological, and rheological studies. Cytotoxicity measurements and imaging against breast cancer cell line MDA-MB-231 unveiled that three out of the five CLMGs can be effectively used for cell imaging. Interestingly, direct use of the metal-containing hybrid gels for live cell imaging which is a distinctive approach, has been successfully achieved with significantly encouraging results.
利用三种不同的发光染料，即吖啶黄（AY）、溴化乙锭（EB）和叠氮硼二吡咯亚甲基，调控异构体锌-三联吡啶配合物C-1（非凝胶剂）和C-2（凝胶剂）的凝胶化性质已被报道。由C-1、C-2和上述染料组合形成的混合凝胶被称为复合发光剂混合凝胶（CLMGs）。随后通过光谱、形态和流变学研究对所得的CLMGs进行了全面表征。针对乳腺癌细胞系MDA-MB-231的细胞毒性测量和成像表明，五种CLMGs中有三种可有效用于细胞成像。有趣的是，直接将含金属的混合凝胶用于活细胞成像，这是一种独特的方法，已成功实现并取得了令人鼓舞的显著结果。
