基于β-CD 修饰透明质酸的超分子纳米粒用于 DNA 包封和控制释放。
Supramolecular nanoparticles based on β-CD modified hyaluronic acid for DNA encapsulation and controlled release.
机构信息
School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300130, P. R. China.
出版信息
Chem Commun (Camb). 2018 Aug 2;54(63):8713-8716. doi: 10.1039/c8cc04783a.
PMID:30023992
Abstract
Supramolecular nanoparticles composed of doubly positively charged adamantane (ADA2+) and β-CD modified hyaluronic acid (HACD) were constructed. When the ester group in ADA2+ was hydrolyzed to a carboxyl group, the quaternary ammonium chain with a positive charge in ADA2+ converted to a "zwitterionic" structure, and the controlled binding and release of pDNA was realized.
摘要
构建了由双正电荷的金刚烷（ADA2+）和 β-CD 修饰的透明质酸（HACD）组成的超分子纳米粒子。当 ADA2+中的酯基水解为羧基时，ADA2+中带正电荷的季铵链转变为“两性离子”结构，实现了 pDNA 的可控结合和释放。
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