超分子大环基纳米材料在癌症治疗中的最新进展。
Recent Advances in Supramolecular-Macrocycle-Based Nanomaterials in Cancer Treatment.
机构信息
Key Laboratory of Functional Polymer Materials (Ministry of Education), College of Chemistry, Nankai University, Tianjin 300071, China.
State Key Laboratory of Medicinal Chemical Biology, College of Chemistry, Nankai University, Tianjin 300071, China.
出版信息
Molecules. 2023 Jan 27;28(3):1241. doi: 10.3390/molecules28031241.
Cancer is a severe threat to human life. Recently, various therapeutic strategies, such as chemotherapy, photodynamic therapy, and combination therapy have been extensively applied in cancer treatment. However, the clinical benefits of these therapeutics still need improvement. In recent years, supramolecular chemistry based on host-guest interactions has attracted increasing attention in biomedical applications to address these issues. In this review, we present the properties of the major macrocyclic molecules and the stimulus-response strategies used for the controlled release of therapeutic agents. Finally, the applications of supramolecular-macrocycle-based nanomaterials in cancer therapy are reviewed, and the existing challenges and prospects are discussed.
癌症是对人类生命的严重威胁。最近，各种治疗策略，如化疗、光动力疗法和联合疗法，已广泛应用于癌症治疗。然而，这些疗法的临床获益仍有待提高。近年来，基于主体-客体相互作用的超分子化学在生物医学应用中受到越来越多的关注，以解决这些问题。在本文综述中，我们介绍了主要大环分子的性质和用于治疗剂控制释放的刺激响应策略。最后，综述了基于超分子-大环的纳米材料在癌症治疗中的应用，并讨论了存在的挑战和前景。
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