Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou 310009, China.
Molecules. 2023 Apr 13;28(8):3441. doi: 10.3390/molecules28083441.
With the development of personalized medical demands for precise diagnosis, rational management and effective cancer treatment, supramolecular theranostic systems have received widespread attention due to their reversibly switchable structures, sensitive response to biological stimuli and integration ability for multiple capabilities in a single platform with a programmable fashion. Cyclodextrins (CDs), benefiting from their excellent characteristics, such as non-toxicity, easy modification, unique host-guest properties, good biocompatibility, etc., as building blocks, serve as an all-purpose strategy for the fabrication of a supramolecular cancer theranostics nanodevice that is capable of biosafety, controllability, functionality and programmability. This review focuses on the supramolecular systems of CD-bioimaging probes, CD-drugs, CD-genes, CD-proteins, CD-photosensitizers and CD-photothermal agents as well as multicomponent cooperation systems with regards to building a nanodevice with functions of diagnosis and (or) therapeutics of cancer treatment. By introducing several state-of-the-art examples, emphasis will be placed on the design of various functional modules, the supramolecular interaction strategies under the fantastic topological structures and the hidden "bridge" between their structures and therapeutic efficacy, aiming for further comprehension of the important role of a cyclodextrin-based nanoplatform in advancing supramolecular cancer theranostics.
随着个性化医疗对精确诊断、合理管理和有效癌症治疗需求的发展，超分子治疗系统因其结构可反复切换、对生物刺激的敏感响应以及以可编程方式将多种功能集成到单个平台中的能力而受到广泛关注。环糊精 (CD) 具有无毒、易修饰、独特的主客体性质、良好的生物相容性等优异特性，可用作构建超分子癌症诊断和治疗纳米器件的通用策略，该纳米器件具有生物安全性、可控性、功能性和可编程性。本综述重点介绍了 CD-生物成像探针、CD-药物、CD-基因、CD-蛋白质、CD-光敏剂和 CD-光热剂的超分子系统以及与构建具有诊断和（或）癌症治疗治疗功能的纳米器件的多组分协同系统。通过介绍几个最新的实例，重点将放在各种功能模块的设计、奇妙拓扑结构下的超分子相互作用策略以及它们的结构和治疗效果之间的隐藏“桥梁”上，旨在进一步理解基于环糊精的纳米平台在推进超分子癌症治疗中的重要作用。
