镁和维生素 E 联合补充对妊娠期糖尿病患者糖稳态和血脂谱参数的影响。
The effects of magnesium and vitamin E co-supplementation on parameters of glucose homeostasis and lipid profiles in patients with gestational diabetes.
机构信息
Endocrinology and Metabolism Research Center, Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
出版信息
Lipids Health Dis. 2018 Jul 20;17(1):163. doi: 10.1186/s12944-018-0814-5.
BACKGROUND
Magnesium and vitamin E are known to exert multiple beneficial effects, such as anti-glycemic and anti-lipidemic properties. The aim of this study was to determine the effects of magnesium and vitamin E co-supplementation on metabolic status of women with gestational diabetes (GDM).
METHODS
This randomized, double-blinded, placebo-controlled trial was conducted among 60 subjects diagnosed with GDM, aged 18-40 years. Subjects were randomly allocated into two groups to receive 250 mg/day magnesium oxide plus 400 IU/day vitamin E supplements or placebo (n = 30 each group) for 6 weeks. Participants' blood samples were taken to determine their metabolic profiles.
RESULTS
Subjects who received magnesium plus vitamin E supplements had significantly lower fasting plasma glucose (β - 5.20 mg/dL; 95% CI, - 7.88, - 2.52; P = 0.002), serum insulin levels (β - 2.93 μIU/mL; 95% CI, - 5.68, - 0.18; P = 0.02) and homeostasis model of assessment-insulin resistance (β - 0.78; 95% CI, - 1.42, - 0.14; P = 0.01), and higher quantitative insulin sensitivity check index (β 0.01; 95% CI, 0.005, 0.02; P = 0.002) compared with placebo. In addition, magnesium plus vitamin E supplementation resulted in a significant reduction in serum triglycerides (β - 50.31 mg/dL; 95% CI, - 67.58, - 33.04; P < 0.001), VLDL- (β - 10.06 mg/dL; 95% CI, - 13.51, - 6.60; P < 0.001), total- (β - 26.10 mg/dL; 95% CI, - 41.88, - 10.33; P = 0.004), LDL- (β - 15.20 mg/dL; 95% CI, - 29.50, - 0.91; P = 0.03) and total-/HDL-cholesterol ratio (β - 0.46; 95% CI, - 0.72, - 0.19; P < 0.001) compared with placebo. Magnesium and vitamin E co-supplementation did not affect HDL-cholesterol levels.
CONCLUSIONS
Overall, magnesium and vitamin E co-supplementation for 6 weeks in women with GDM significantly improved glycemic control and lipid profiles, except for HDL-cholesterol levels.
CLINICAL TRIAL REGISTRATION NUMBER
http://www.irct.ir : IRCT20170513033941N24.
背景
镁和维生素 E 已知具有多种有益作用，如抗血糖和抗血脂作用。本研究旨在确定镁和维生素 E 联合补充对妊娠期糖尿病（GDM）女性代谢状态的影响。
方法
这项随机、双盲、安慰剂对照试验在 60 名被诊断为 GDM 的 18-40 岁女性中进行。受试者被随机分为两组，分别服用 250mg/天氧化镁加 400IU/天维生素 E 补充剂或安慰剂（每组 30 人），持续 6 周。采集参与者的血样以确定其代谢谱。
结果
接受镁加维生素 E 补充剂的受试者空腹血糖（β - 5.20mg/dL；95%CI，-7.88，-2.52；P=0.002）、血清胰岛素水平（β - 2.93μIU/mL；95%CI，-5.68，-0.18；P=0.02）和胰岛素抵抗评估的稳态模型（β - 0.78；95%CI，-1.42，-0.14；P=0.01）显著降低，而定量胰岛素敏感性检查指数（β 0.01；95%CI，0.005，0.02；P=0.002）则升高与安慰剂相比。此外，镁加维生素 E 补充剂可显著降低血清甘油三酯（β - 50.31mg/dL；95%CI，-67.58，-33.04；P<0.001）、极低密度脂蛋白（β - 10.06mg/dL；95%CI，-13.51，-6.60；P<0.001）、总胆固醇（β - 26.10mg/dL；95%CI，-41.88，-10.33；P=0.004）、LDL-（β - 15.20mg/dL；95%CI，-29.50，-0.91；P=0.03）和总胆固醇/高密度脂蛋白胆固醇比值（β - 0.46；95%CI，-0.72，-0.19；P<0.001）与安慰剂相比。镁和维生素 E 联合补充对 HDL-胆固醇水平没有影响。
结论
总体而言，镁和维生素 E 联合补充 6 周可显著改善 GDM 女性的血糖控制和血脂谱，除了 HDL-胆固醇水平。
临床试验注册编号
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