Hosseini Dastgerdi Azadehalsadat, Ghanbari Rad Mahtab, Soltani Nepton
Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2022 Jun 29;11:54. doi: 10.4103/abr.abr_366_21. eCollection 2022.
Insulin resistance (IR) is a chronic pathological condition that is related to reduce the rates of glucose uptake, especially in the liver, muscle, and adipose tissue as target tissues. Metabolic syndrome and type 2 diabetes mellitus can occur following progression of the disease. The majority of prior research has applied that some cations such as magnesium (Mg) have important physiological role in insulin metabolism. Mg is the fourth most abundant mineral in the human body that gets involved as a cofactor of various enzymes in several metabolic events, such as carbohydrate oxidation, and it has a fundamental role in glucose transporting mechanism of the cell membrane. This cation has numerous duties in the human body such as regulation of insulin secretion in pancreatic beta-cells and phosphorylation of the insulin receptors in target cells and also gets involved in other downstream signal kinases as intracellular cation. On this basis, intracellular Mg balancing is vital for adequate carbohydrate metabolism. This paper summarizes the present knowledge about the therapeutic effects of Mg in reducing IR in liver, muscle, and pancreases with different mechanisms. For this, the search was performed in Google Scholar, PubMed, Scopus, and Web of Science by insulin resistance, skeletal muscle, liver, pancreases, magnesium, Mg, and inflammation keywords.
胰岛素抵抗（IR）是一种慢性病理状态，与葡萄糖摄取率降低有关，尤其是在作为靶组织的肝脏、肌肉和脂肪组织中。随着病情进展，可能会出现代谢综合征和2型糖尿病。先前的大多数研究表明，一些阳离子如镁（Mg）在胰岛素代谢中具有重要的生理作用。镁是人体中含量第四丰富的矿物质，作为多种酶的辅助因子参与多种代谢过程，如碳水化合物氧化，并且在细胞膜的葡萄糖转运机制中起着重要作用。这种阳离子在人体中有许多作用，如调节胰腺β细胞中的胰岛素分泌和靶细胞中胰岛素受体的磷酸化，并且作为细胞内阳离子还参与其他下游信号激酶。在此基础上，细胞内镁平衡对于充分的碳水化合物代谢至关重要。本文总结了目前关于镁通过不同机制降低肝脏、肌肉和胰腺中胰岛素抵抗的治疗作用的知识。为此，通过胰岛素抵抗、骨骼肌、肝脏、胰腺、镁、Mg和炎症等关键词在谷歌学术、PubMed、Scopus和科学网中进行了检索。
