Department of Infectious Disease, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Infections Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Wound Repair Regen. 2019 May;27(3):277-284. doi: 10.1111/wrr.12701. Epub 2019 Feb 11.
This study was carried out to determine the effects of magnesium and vitamin E co-supplementation on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double-blind, placebo-controlled trial was conducted among 57 patients with grade 3 DFU. Participants were randomly divided into two groups to take either 250 mg magnesium oxide plus 400 IU vitamin E (n = 29) or placebo per day (n = 28) for 12 weeks. Compared with the placebo, taking magnesium plus vitamin E supplements reduced ulcer length (β [difference in the mean of outcomes measures between treatment groups] -0.56 cm; 95% CI, -0.92, -0.20; p = 0.003), width (β -0.35 cm; 95% CI, -0.64, -0.05; p = 0.02) and depth (β -0.18 cm; 95% CI, -0.33, -0.02; p = 0.02). In addition, co-supplementation led to a significant reduction in fasting plasma glucose (β -13.41 mg/dL; 95% CI, -20.96, -5.86; p = 0.001), insulin (β -1.45 μIU/ml; 95% CI, -2.37, -0.52; p = 0.003), insulin resistance (β -0.60; 95% CI, -0.99, -0.20; p = 0.003) and HbA1c (β -0.32%; 95% CI, -0.48, -0.16; p < 0.003), and a significant elevation in insulin sensitivity (β 0.007; 95% CI, 0.003, 0.01; p < 0.001) compared with the placebo. Additionally, compared with the placebo, taking magnesium plus vitamin E supplements decreased triglycerides (β -10.08 mg/dL; 95% CI, -19.70, -0.46; p = 0.04), LDL-cholesterol (β -5.88 mg/dL; 95% CI, -11.42, -0.34; p = 0.03), high sensitivity C-reactive protein (hs-CRP) (β -3.42 mg/L; 95% CI, -4.44, -2.41; p < 0.001) and malondialdehyde (MDA) (β -0.30 μmol/L; 95% CI, -0.45, -0.15; p < 0.001), and increased HDL-cholesterol (β 2.62 mg/dL; 95% CI, 0.60, 4.63; p = 0.01) and total antioxidant capacity (TAC) levels (β 53.61 mmol/L; 95% CI, 4.65, 102.57; p = 0.03). Overall, magnesium and vitamin E co-supplementation for 12 weeks to patients with DFU had beneficial effects on ulcer size, glycemic control, triglycerides, LDL- and HDL-cholesterol, hs-CRP, TAC, and MDA levels.
本研究旨在确定镁和维生素 E 联合补充对糖尿病足溃疡（DFU）患者伤口愈合和代谢状态的影响。目前的随机、双盲、安慰剂对照试验在 57 名 3 级 DFU 患者中进行。参与者被随机分为两组，分别每天服用 250mg 氧化镁加 400IU 维生素 E（n=29）或安慰剂（n=28），共 12 周。与安慰剂相比，服用镁加维生素 E 补充剂可减少溃疡长度（β差异治疗组之间的结局指标平均值[0.56cm；95%CI，-0.92，-0.20；p=0.003]）、宽度（β -0.35cm；95%CI，-0.64，-0.05；p=0.02）和深度（β -0.18cm；95%CI，-0.33，-0.02；p=0.02）。此外，联合补充可显著降低空腹血糖（β -13.41mg/dL；95%CI，-20.96，-5.86；p=0.001）、胰岛素（β -1.45μIU/ml；95%CI，-2.37，-0.52；p=0.003）、胰岛素抵抗（β -0.60；95%CI，-0.99，-0.20；p=0.003）和糖化血红蛋白（HbA1c）（β -0.32%；95%CI，-0.48，-0.16；p<0.003），并显著提高胰岛素敏感性（β 0.007；95%CI，0.003，0.01；p<0.001）与安慰剂相比。此外，与安慰剂相比，服用镁加维生素 E 补充剂可降低甘油三酯（β -10.08mg/dL；95%CI，-19.70，-0.46；p=0.04）、LDL-胆固醇（β -5.88mg/dL；95%CI，-11.42，-0.34；p=0.03）、高敏 C 反应蛋白（hs-CRP）（β -3.42mg/L；95%CI，-4.44，-2.41；p<0.001）和丙二醛（MDA）（β -0.30μmol/L；95%CI，-0.45，-0.15；p<0.001），并提高高密度脂蛋白胆固醇（β 2.62mg/dL；95%CI，0.60，4.63；p=0.01）和总抗氧化能力（TAC）水平（β 53.61mmol/L；95%CI，4.65，102.57；p=0.03）。总的来说，DFU 患者补充镁和维生素 E 联合治疗 12 周对溃疡大小、血糖控制、甘油三酯、LDL 和 HDL-胆固醇、hs-CRP、TAC 和 MDA 水平均有有益影响。
