Rahatli Feride Kural, Turnaoglu Hale, Iyidir Ozlem Turhan, Kirnap Nazli Gulsoy, Haberal Kemal Murat, Aydın Erdinç, Uslu Nihal
Department of Radiology, Faculty of Medicine, Baskent University, Ankara, Turkey.
Department of Endocrinology, Faculty of Medicine, Baskent University, Ankara, Turkey.
J Ultrasound Med. 2019 Feb;38(2):357-362. doi: 10.1002/jum.14695. Epub 2018 Jul 19.
Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy. Radioactive iodine (RAI) therapy is used for remnant ablation following thyroidectomy. Side effects such as dysphagia, xerostomia, and sialoadenitis may occur. We aimed to determine the differences in the parotid and submandibulary glands between healthy patients and patients with PTC who had undergone RAI therapy and have dry mouth symptoms using both shear wave elastography and ultrasonography.
We enrolled 30 patients with PTC who had undergone RAI therapy following surgery and 30 healthy controls. Ultrasonography and shear wave elastography of submandibular and parotid glands were performed. The volume of the submandibular glands and the thickness of parotid glands were determined. Ten independent measurements were obtained from each gland, with the region of interest placed at different points on the glands. The mean shear wave velocities (SWVs) were calculated and compared between the patients and controls.
In the PTC group, there was a significant reduction in the volume of the submandibular glands (P < .05) and in the thickness of the parotid glands (P < .05) compared with the control group. The mean SWVs of the parotid glands and submandibular glands were significantly higher in the PTC group compared with the control group (P < .0001). The SWVs of the parotid glands were higher than the SWVs of the submandibular glands (P < .0001).
Shear wave elastography could be a noninvasive and easy assessment method of parotid and submandibular glands in patients who had undergone RAI therapy and experience dry mouth.
乳头状甲状腺癌（PTC）是最常见的甲状腺恶性肿瘤。放射性碘（RAI）治疗用于甲状腺切除术后的残余甲状腺组织消融。可能会出现吞咽困难、口干和涎腺炎等副作用。我们旨在通过剪切波弹性成像和超声检查，确定健康患者与接受过RAI治疗且有口干症状的PTC患者腮腺和颌下腺之间的差异。
我们纳入了30例接受过手术后RAI治疗的PTC患者和30名健康对照者。对颌下腺和腮腺进行了超声检查和剪切波弹性成像检查。测定了颌下腺的体积和腮腺的厚度。从每个腺体获得10次独立测量值，感兴趣区域放置在腺体的不同点上。计算并比较患者和对照组之间的平均剪切波速度（SWV）。
与对照组相比，PTC组颌下腺体积（P＜0.05）和腮腺厚度（P＜0.05）均显著减小。与对照组相比，PTC组腮腺和颌下腺的平均SWV显著更高（P＜0.0001）。腮腺的SWV高于颌下腺的SWV（P＜0.0001）。
剪切波弹性成像可能是一种对接受过RAI治疗且有口干症状的患者腮腺和颌下腺进行无创且简便的评估方法。
