Department of Physics and Center for Complex Systems, National Central University, Jhongli, Taiwan 32001, Republic of China.
Department of Biomedical Sciences and Engineering, National Central University, Jhongli, Taiwan 32001, Republic of China.
Phys Rev Lett. 2018 Jul 6;121(1):018101. doi: 10.1103/PhysRevLett.121.018101.
We report the experimental observation of speeded-up collective motion of the monolayer endothelia-cancer mixture on a collagen-coated substrate, after the invasion of a small fraction of motile cancer cells into the confluent endothelial monolayer, through disrupting cell-cell junctions. It is found that, with an increasing waiting time, the cancer-free confluent endothelial monolayer exhibits a dynamical slowing-down of liquidlike micromotion with a gradually decreasing degree of superdiffusion. After invasion, cancer cells aggregate and exhibit turbulentlike cooperative motion, which is enhanced with the increasing size of gradually aggregated cancer clusters, confined by the fluctuating boundaries of surrounding endothelial cells. It, in turn, enhances the surrounding endothelial cell motion and speeds up the originally slowed-down motion.
我们报告了在一小部分运动癌细胞侵入到融合的内皮单层细胞后，通过破坏细胞-细胞连接，单层内皮-癌细胞混合物在胶原涂覆的基底上的加速集体运动的实验观察。研究发现，随着等待时间的增加，无癌的融合内皮单层细胞的液态微运动表现出动态减速，超扩散程度逐渐减小。入侵后，癌细胞聚集并表现出类湍流的协作运动，随着逐渐聚集的癌细胞簇的尺寸增加而增强，受周围内皮细胞的波动边界限制。这反过来又增强了周围内皮细胞的运动，并加速了原本减速的运动。
